Single-cell hdWGCNA reveals metastatic protective macrophages and development of deep learning model in uveal melanoma.

Journal: Journal of translational medicine
PMID: 39075441

Abstract

BACKGROUND: Although there has been some progress in the treatment of primary uveal melanoma (UVM), distant metastasis remains the leading cause of death in patients. Monitoring, staging, and treatment of metastatic disease have not yet reached consensus. Although more than half of metastatic tumors (62%) are diagnosed within five years after primary tumor treatment, the remainder are only detected in the following 25 years. The mechanisms of UVM metastasis and its impact on prognosis are not yet fully understood.

Authors

  • Yifang Sun
    Department of Ophthalmology, Guangzhou Red Cross Hospital of Jinan University, Guangzhou, Guangdong, 510220, China.
  • Jian Wu
    Department of Medical Technology, Jiangxi Medical College, Shangrao, Jiangxi, China.
  • Qian Zhang
    The Neonatal Intensive Care Unit, Peking Union Medical College Hospital, Peking, China.
  • Pengzhen Wang
    Guangzhou Institute of Traumatic Surgery, Guangzhou Red Cross Hospital of Jinan University, Guangdong, 510220, China.
  • Jinglin Zhang
    Guangzhou Aier Eye Hospital, Jinan University, Guangzhou, China.
  • Yonggang Yuan
    Department of Ophthalmology, Guangzhou Red Cross Hospital of Jinan University, Guangzhou, Guangdong, 510220, China. ophthalmology2022@163.com.

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