CPT: pharmacometrics & systems pharmacology
Jul 11, 2024
The advent of machine learning has led to innovative approaches in dealing with clinical data. Among these, Neural Ordinary Differential Equations (Neural ODEs), hybrid models merging mechanistic with deep learning models have shown promise in accura...
CPT: pharmacometrics & systems pharmacology
Jun 14, 2024
We address the problem of model misspecification in population pharmacokinetics (PopPK), by modeling residual unexplained variability (RUV) by machine learning (ML) methods in a postprocessing step after conventional model building. The practical pur...
CPT: pharmacometrics & systems pharmacology
Mar 11, 2024
Noncompartmental analysis (NCA) is a model-independent approach for assessing pharmacokinetics (PKs). Although the existing NCA algorithms are very well-established and widely utilized, they suffer from low accuracies in the setting of sparse PK samp...
CPT: pharmacometrics & systems pharmacology
Dec 5, 2023
Despite attempts to control the spread of human immunodeficiency virus (HIV) through the use of anti-HIV medications, the absence of an effective vaccine continues to present a significant obstacle. In addition, the development of drug resistance by ...
CPT: pharmacometrics & systems pharmacology
Oct 16, 2023
Recently, the use of machine-learning (ML) models for pharmacokinetic (PK) modeling has grown significantly. Although most of the current approaches use ML techniques as black boxes, there are only a few that have proposed interpretable architectures...
CPT: pharmacometrics & systems pharmacology
Apr 24, 2023
When aiming to make predictions over targets in the pharmacological setting, a data-focused approach aims to learn models based on a collection of labeled examples. Unfortunately, data sharing is not always possible, and this can result in many diffe...
CPT: pharmacometrics & systems pharmacology
Mar 31, 2023
Oncology treatments require continuous individual adjustment based on the measurement of multiple clinical parameters. Prediction tools exploiting the patterns present in the clinical data could be used to assist decision making and ease the burden a...
CPT: pharmacometrics & systems pharmacology
Mar 5, 2023
Artificial intelligence (AI) has come to be used in various technological fields in recent years. However, there have been no reports of AI-designed clinical trials. In this study, we tried to develop study designs by a genetic algorithm (GA), which ...