AI Medical Compendium Journal:
The Journal of pharmacology and experimental therapeutics

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Identification of Glucose Transport Modulators In Vitro and Method for Their Deep Learning Neural Network Behavioral Evaluation in Glucose Transporter 1-Deficient Mice.

The Journal of pharmacology and experimental therapeutics Jan 12, 2023
Metabolic flux augmentation via glucose transport activation may be desirable in glucose transporter 1 (Glut1) deficiency syndrome (G1D) and dementia, whereas suppression might prove useful in cancer. Using lung adenocarcinoma cells that predominantl...
Humans Animals Deep Learning Mice Glucose Carbohydrate Metabolism, Inborn Errors Glucose Transporter Type 1 Monosaccharide Transport Proteins
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Molecular Properties of Drugs Interacting with SLC22 Transporters OAT1, OAT3, OCT1, and OCT2: A Machine-Learning Approach.

The Journal of pharmacology and experimental therapeutics Aug 3, 2016
Statistical analysis was performed on physicochemical descriptors of ∼250 drugs known to interact with one or more SLC22 "drug" transporters (i.e., SLC22A6 or OAT1, SLC22A8 or OAT3, SLC22A1 or OCT1, and SLC22A2 or OCT2), followed by application of ma...
Machine Learning Protein Binding Computational Biology Models, Molecular Pharmaceutical Preparations Hydrogen-Ion Concentration Membrane Transport Proteins Protein Conformation Substrate Specificity Organic Anion Transport Protein 1 Organic Anion Transporters, Sodium-Independent Organic Cation Transporter 1
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