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Organic Cation Transporter 1

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Molecular Properties of Drugs Interacting with SLC22 Transporters OAT1, OAT3, OCT1, and OCT2: A Machine-Learning Approach.

The Journal of pharmacology and experimental therapeutics 27488918
Statistical analysis was performed on physicochemical descriptors of ∼250 drugs known to interact with one or more SLC22 "drug" transporters (i.e., SLC22A6 or OAT1, SLC22A8 or OAT3, SLC22A1 or OCT1, and SLC22A2 or OCT2), followed by application of ma...
Computational Biology Hydrogen-Ion Concentration Machine Learning Membrane Transport Proteins Models, Molecular Organic Anion Transport Protein 1 Organic Anion Transporters, Sodium-Independent Organic Cation Transporter 1 Pharmaceutical Preparations Protein Binding Protein Conformation Substrate Specificity
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Interaction of systemic drugs causing ocular toxicity with organic cation transporter: an artificial intelligence prediction.

Journal of biomolecular structure & dynamics 37340665
Chronic disease patients (cancer, arthritis, cardiovascular diseases) undergo long-term systemic drug treatment. Membrane transporters in ocular barriers could falsely recognize these drugs and allow their trafficking into the eye from systemic circu...
Artificial Intelligence Binding Sites Humans Ligands Machine Learning Molecular Docking Simulation Molecular Dynamics Simulation Organic Cation Transport Proteins Organic Cation Transporter 1 Protein Binding
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