AIMC Topic: Organic Cation Transporter 1

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Substrate Specificity of the Organic Cation Transporters MATE1 and MATE2K and Functional Overlap with OCT1 and OCT2.

Journal of medicinal chemistry Jun 13, 2025
The multidrug and toxin extrusion proteins MATE1 and MATE2K may determine the pharmacokinetics and drug-drug interactions of many drugs. However, their substrate spectrum and synergy with organic cation transporters OCT1 and OCT2 remain incompletely ...
Humans Chromatography, High Pressure Liquid Tandem Mass Spectrometry HEK293 Cells Substrate Specificity Organic Cation Transport Proteins Organic Cation Transporter 1 Organic Cation Transporter 2
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Interaction of systemic drugs causing ocular toxicity with organic cation transporter: an artificial intelligence prediction.

Journal of biomolecular structure & dynamics Jun 20, 2023
Chronic disease patients (cancer, arthritis, cardiovascular diseases) undergo long-term systemic drug treatment. Membrane transporters in ocular barriers could falsely recognize these drugs and allow their trafficking into the eye from systemic circu...
Humans Artificial Intelligence Machine Learning Molecular Docking Simulation Protein Binding Molecular Dynamics Simulation Ligands Binding Sites Organic Cation Transport Proteins Organic Cation Transporter 1
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Molecular Properties of Drugs Interacting with SLC22 Transporters OAT1, OAT3, OCT1, and OCT2: A Machine-Learning Approach.

The Journal of pharmacology and experimental therapeutics Aug 3, 2016
Statistical analysis was performed on physicochemical descriptors of ∼250 drugs known to interact with one or more SLC22 "drug" transporters (i.e., SLC22A6 or OAT1, SLC22A8 or OAT3, SLC22A1 or OCT1, and SLC22A2 or OCT2), followed by application of ma...
Machine Learning Protein Binding Computational Biology Models, Molecular Pharmaceutical Preparations Hydrogen-Ion Concentration Membrane Transport Proteins Protein Conformation Substrate Specificity Organic Anion Transport Protein 1 Organic Anion Transporters, Sodium-Independent Organic Cation Transporter 1
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