AIMC Topic: Membrane Transport Proteins

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NA_mCNN: Classification of Sodium Transporters in Membrane Proteins by Integrating Multi-Window Deep Learning and ProtTrans for Their Therapeutic Potential.

Journal of proteome research Apr 7, 2025
Sodium transporters maintain cellular homeostasis by transporting ions, minerals, and nutrients across the membrane, and Na+/K+ ATPases facilitate the cotransport of solutes in neurons, muscle cells, and epithelial cells. Sodium transporters are impo...
Membrane Proteins Sodium Membrane Transport Proteins Humans Deep Learning
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Computational Chemistry in Structure-Based Solute Carrier Transporter Drug Design: Recent Advances and Future Perspectives.

Journal of chemical information and modeling Jan 31, 2024
Solute carrier transporters (SLCs) are a class of important transmembrane proteins that are involved in the transportation of diverse solute ions and small molecules into cells. There are approximately 450 SLCs within the human body, and more than a ...
Humans Drug Discovery Membrane Transport Proteins Computational Chemistry Artificial Intelligence Drug Design
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PortPred: Exploiting deep learning embeddings of amino acid sequences for the identification of transporter proteins and their substrates.

Journal of cellular biochemistry Oct 25, 2023
The physiology of every living cell is regulated at some level by transporter proteins which constitute a relevant portion of membrane-bound proteins and are involved in the movement of ions, small and macromolecules across bio-membranes. The importa...
Computational Biology Machine Learning Amino Acid Sequence Membrane Transport Proteins Membrane Proteins Deep Learning
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Machine Learning Techniques Applied to the Study of Drug Transporters.

Molecules (Basel, Switzerland) Aug 8, 2023
With the advancement of computer technology, machine learning-based artificial intelligence technology has been increasingly integrated and applied in the fields of medicine, biology, and pharmacy, thereby facilitating their development. Transporters...
Artificial Intelligence Machine Learning ATP Binding Cassette Transporter, Subfamily G, Member 2 Neoplasm Proteins Membrane Transport Proteins
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In silico investigation on structure-function relationship of members belonging to the human SLC52 transporter family.

Proteins Dec 23, 2022
Riboflavin is an essential water-soluble vitamin that needs to be provided through the diet because of the conversion into flavin adenine dinucleotide (FAD) and flavin mononucleotide (FMN), important cofactors in hundreds of flavoenzymes. The adsorpt...
Structure-Activity Relationship Membrane Transport Proteins Riboflavin Humans Artificial Intelligence Flavin Mononucleotide Hearing Loss, Sensorineural Flavin-Adenine Dinucleotide
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Trivariate Linear Regression and Machine Learning Prediction of Possible Roles of Efflux Transporters in Estimated Intestinal Permeability Values of 301 Disparate Chemicals.

Biological & pharmaceutical bulletin May 27, 2022
A system for predicting apparent bidirectional permeability (P) across Caco-2 cells of diverse chemicals has been reported. The present study aimed to investigate the relationship between in silico-generated P (from apical to basal side, P) for 301 s...
Caco-2 Cells Biological Transport Linear Models Membrane Transport Proteins Permeability Humans Machine Learning
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Exploring the conformational diversity of proteins.

eLife Apr 21, 2022
An artificial intelligence-based method can predict distinct conformational states of membrane transporters and receptors.
Molecular Conformation Membrane Transport Proteins Artificial Intelligence Molecular Dynamics Simulation
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Kernel machine SNP set analysis finds the association of BUD13, ZPR1, and APOA5 variants with metabolic syndrome in Tehran Cardio-metabolic Genetics Study.

Scientific reports May 13, 2021
Metabolic syndrome (MetS) is one of the most important risk factors for cardiovascular disease. The 11p23.3 chromosomal region plays a potential role in the pathogenesis of MetS. The present study aimed to assess the association between 18 single nuc...
Humans Female Male Machine Learning Membrane Transport Proteins Genetic Predisposition to Disease RNA-Binding Proteins Metabolic Syndrome Cardiometabolic Risk Factors Apolipoprotein A-V Polymorphism, Single Nucleotide Iran
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Analysis of gene expression profiles of lung cancer subtypes with machine learning algorithms.

Biochimica et biophysica acta. Molecular basis of disease Apr 28, 2020
Lung cancer is one of the most common cancer types worldwide and causes more than one million deaths annually. Lung adenocarcinoma (AC) and lung squamous cell cancer (SCC) are two major lung cancer subtypes and have different characteristics in sever...
Cystatin A Datasets as Topic Tumor Suppressor Proteins Adenosine Triphosphatases Diagnosis, Differential Transcriptome Carcinoma, Squamous Cell Monte Carlo Method Serpins Terminology as Topic Lung Neoplasms Cadherins Gene Expression Profiling Adenocarcinoma of Lung Humans Membrane Transport Proteins Gene Expression Regulation, Neoplastic Computational Biology Machine Learning Transcription Factors
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TooT-T: discrimination of transport proteins from non-transport proteins.

BMC bioinformatics Apr 23, 2020
BACKGROUND: Membrane transport proteins (transporters) play an essential role in every living cell by transporting hydrophilic molecules across the hydrophobic membranes. While the sequences of many membrane proteins are known, their structure and fu...
Membrane Transport Proteins Computational Biology Support Vector Machine Amino Acid Sequence Machine Learning
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