AIMC Topic: Acetyl-CoA Carboxylase

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Combined structure-based virtual screening and machine learning approach for the identification of potential dual inhibitors of ACC and DGAT2.

International journal of biological macromolecules Jul 31, 2024
Acetyl-coenzyme A carboxylase (ACC) and diacylglycerol acyltransferase 2 (DGAT2) are recognized as potential therapeutic targets for nonalcoholic fatty liver disease (NAFLD). Inhibitors targeting ACC and DGAT2 have exhibited the capacity to reduce he...
Humans Machine Learning Molecular Docking Simulation Protein Binding Molecular Dynamics Simulation Drug Evaluation, Preclinical Non-alcoholic Fatty Liver Disease Enzyme Inhibitors Binding Sites Diacylglycerol O-Acyltransferase Acetyl-CoA Carboxylase
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