AIMC Topic: Diacylglycerol O-Acyltransferase

Clear Filters Showing 1 to 5 of 5 articles

Comprehensive bioinformatics analysis and experimental verification identify mitochondrial gene Dgat2 as a novel therapeutic biomarker for myocardial ischemia-reperfusion.

Frontiers in endocrinology May 29, 2025
BACKGROUND: Ischemic cardiomyopathy is a severe disease marked by high morbidity and mortality, often exacerbated by myocardial ischemia/reperfusion injury (MI/RI). Mitochondrial metabolism plays a critical role in MI/RI progression. This study aimed...
Protein Interaction Maps Gene Regulatory Networks Mice Animals Male Genes, Mitochondrial Myocardial Reperfusion Injury Diacylglycerol O-Acyltransferase Computational Biology Mice, Inbred C57BL Biomarkers
View on PubMed DOI

Combined structure-based virtual screening and machine learning approach for the identification of potential dual inhibitors of ACC and DGAT2.

International journal of biological macromolecules Jul 31, 2024
Acetyl-coenzyme A carboxylase (ACC) and diacylglycerol acyltransferase 2 (DGAT2) are recognized as potential therapeutic targets for nonalcoholic fatty liver disease (NAFLD). Inhibitors targeting ACC and DGAT2 have exhibited the capacity to reduce he...
Humans Machine Learning Molecular Docking Simulation Enzyme Inhibitors Binding Sites Acetyl-CoA Carboxylase Diacylglycerol O-Acyltransferase Protein Binding Molecular Dynamics Simulation Drug Evaluation, Preclinical Non-alcoholic Fatty Liver Disease
View on PubMed DOI

Highly accurate protein structure prediction for the human proteome.

Nature Jul 22, 2021
Protein structures can provide invaluable information, both for reasoning about biological processes and for enabling interventions such as structure-based drug development or targeted mutagenesis. After decades of effort, 17% of the total residues i...
Protein Conformation Diacylglycerol O-Acyltransferase Models, Molecular Datasets as Topic Protein Folding Glucose-6-Phosphatase Reproducibility of Results Deep Learning Proteome Membrane Proteins Computational Biology Humans
View on PubMed DOI

Discovery of novel DGAT1 inhibitors by combination of machine learning methods, pharmacophore model and 3D-QSAR model.

Molecular diversity Jun 23, 2021
DGAT1 plays a crucial controlling role in triglyceride biosynthetic pathways, which makes it an attractive therapeutic target for obesity. Thus, development of DGAT1 inhibitors with novel chemical scaffolds is desired and important in the drug discov...
Cheminformatics Quantitative Structure-Activity Relationship Diacylglycerol O-Acyltransferase Humans Machine Learning Models, Molecular Molecular Structure Enzyme Inhibitors Databases, Chemical Molecular Dynamics Simulation Algorithms Reproducibility of Results Drug Discovery Molecular Docking Simulation ROC Curve
View on PubMed DOI

Adaptations to excess choline in insulin resistant and Pcyt2 deficient skeletal muscle.

Biochemistry and cell biology = Biochimie et biologie cellulaire Sep 6, 2016
It was hypothesized that choline supplementation in insulin resistant (IR) CTP:phosphoethanolamine cytidylyltransferase deficient (Pcyt2) mice would ameliorate muscle function by remodeling glucose and fatty acid (FA) metabolism. Pcyt2 mice either re...
RNA Nucleotidyltransferases PPAR alpha Sterol Regulatory Element Binding Protein 1 Triglycerides Insulin Receptor Substrate Proteins Choline fas Receptor Carnitine O-Palmitoyltransferase Muscle, Skeletal Diacylglycerol O-Acyltransferase Insulin Resistance Fatty Acids Organic Cation Transport Proteins Gene Expression Regulation Mice, Knockout Animals Administration, Oral Signal Transduction Stearoyl-CoA Desaturase Microtubule-Associated Proteins Glucose Lipogenesis Mice Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha Adaptation, Physiological
View on PubMed DOI
Popular Topics
Recent Journals