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Diacylglycerol O-Acyltransferase

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Adaptations to excess choline in insulin resistant and Pcyt2 deficient skeletal muscle.

Biochemistry and cell biology = Biochimie et biologie cellulaire 28068143
It was hypothesized that choline supplementation in insulin resistant (IR) CTP:phosphoethanolamine cytidylyltransferase deficient (Pcyt2) mice would ameliorate muscle function by remodeling glucose and fatty acid (FA) metabolism. Pcyt2 mice either re...
Adaptation, Physiological Administration, Oral Animals Carnitine O-Palmitoyltransferase Choline Diacylglycerol O-Acyltransferase fas Receptor Fatty Acids Gene Expression Regulation Glucose Insulin Receptor Substrate Proteins Insulin Resistance Lipogenesis Mice Mice, Knockout Microtubule-Associated Proteins Muscle, Skeletal Organic Cation Transport Proteins Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha PPAR alpha RNA Nucleotidyltransferases Signal Transduction Stearoyl-CoA Desaturase Sterol Regulatory Element Binding Protein 1 Triglycerides
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Discovery of novel DGAT1 inhibitors by combination of machine learning methods, pharmacophore model and 3D-QSAR model.

Molecular diversity 34160713
DGAT1 plays a crucial controlling role in triglyceride biosynthetic pathways, which makes it an attractive therapeutic target for obesity. Thus, development of DGAT1 inhibitors with novel chemical scaffolds is desired and important in the drug discov...
Algorithms Cheminformatics Databases, Chemical Diacylglycerol O-Acyltransferase Drug Discovery Enzyme Inhibitors Humans Machine Learning Models, Molecular Molecular Docking Simulation Molecular Dynamics Simulation Molecular Structure Quantitative Structure-Activity Relationship Reproducibility of Results ROC Curve
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Highly accurate protein structure prediction for the human proteome.

Nature 34293799
Protein structures can provide invaluable information, both for reasoning about biological processes and for enabling interventions such as structure-based drug development or targeted mutagenesis. After decades of effort, 17% of the total residues i...
Computational Biology Datasets as Topic Deep Learning Diacylglycerol O-Acyltransferase Glucose-6-Phosphatase Humans Membrane Proteins Models, Molecular Protein Conformation Protein Folding Proteome Reproducibility of Results
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Combined structure-based virtual screening and machine learning approach for the identification of potential dual inhibitors of ACC and DGAT2.

International journal of biological macromolecules 39089556
Acetyl-coenzyme A carboxylase (ACC) and diacylglycerol acyltransferase 2 (DGAT2) are recognized as potential therapeutic targets for nonalcoholic fatty liver disease (NAFLD). Inhibitors targeting ACC and DGAT2 have exhibited the capacity to reduce he...
Acetyl-CoA Carboxylase Binding Sites Diacylglycerol O-Acyltransferase Drug Evaluation, Preclinical Enzyme Inhibitors Humans Machine Learning Molecular Docking Simulation Molecular Dynamics Simulation Non-alcoholic Fatty Liver Disease Protein Binding
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