AIMC Topic: Active Transport, Cell Nucleus

Clear Filters Showing 1 to 2 of 2 articles

Deep learning prioritizes cancer mutations that alter protein nucleocytoplasmic shuttling to drive tumorigenesis.

Nature communications Mar 14, 2025
Genetic variants can affect protein function by driving aberrant subcellular localization. However, comprehensive analysis of how mutations promote tumor progression by influencing nuclear localization is currently lacking. Here, we systematically ch...
Humans Neoplasms Deep Learning Carcinogenesis Mutation Cell Nucleus Cytoplasm Nuclear Localization Signals PTEN Phosphohydrolase Active Transport, Cell Nucleus
View on PubMed DOI

AI-based structure prediction empowers integrative structural analysis of human nuclear pores.

Science (New York, N.Y.) Jun 10, 2022
INTRODUCTION The eukaryotic nucleus pro-tects the genome and is enclosed by the two membranes of the nuclear envelope. Nuclear pore complexes (NPCs) perforate the nuclear envelope to facilitate nucleocytoplasmic transport. With a molecular weight of ...
Humans Artificial Intelligence Proteomics Molecular Dynamics Simulation Cryoelectron Microscopy Nuclear Pore Complex Proteins Nuclear Pore Active Transport, Cell Nucleus
View on PubMed DOI
Popular Topics
Recent Journals