AIMC Topic: Nuclear Localization Signals

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Deep learning prioritizes cancer mutations that alter protein nucleocytoplasmic shuttling to drive tumorigenesis.

Nature communications Mar 14, 2025
Genetic variants can affect protein function by driving aberrant subcellular localization. However, comprehensive analysis of how mutations promote tumor progression by influencing nuclear localization is currently lacking. Here, we systematically ch...
Humans Neoplasms Deep Learning Carcinogenesis Mutation Cell Nucleus Cytoplasm Nuclear Localization Signals PTEN Phosphohydrolase Active Transport, Cell Nucleus
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Discovering nuclear targeting signal sequence through protein language learning and multivariate analysis.

Analytical biochemistry Dec 26, 2019
Nuclear localization signals (NLSs) are peptides that target proteins to the nucleus by binding to carrier proteins in the cytoplasm that transport their cargo across the nuclear membrane. Accurate identification of NLSs can help elucidate the functi...
Machine Learning Databases, Protein Natural Language Processing Amino Acid Sequence Nuclear Localization Signals
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Simultaneous delivery of anti-miR21 with doxorubicin prodrug by mimetic lipoprotein nanoparticles for synergistic effect against drug resistance in cancer cells.

International journal of nanomedicine Dec 30, 2016
The development of drug resistance in cancer cells is one of the major obstacles to achieving effective chemotherapy. We hypothesized that the combination of a doxorubicin (Dox) prodrug and microRNA (miR)21 inhibitor might show synergistic antitumor ...
Humans Female Animals Antineoplastic Agents Cell Line, Tumor Nanoparticles Mice, Nude Apoptosis MicroRNAs Lipids MCF-7 Cells Doxorubicin Prodrugs Drug Resistance, Neoplasm Lipoproteins, HDL Nuclear Localization Signals Receptors, Lipoprotein
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