While advances in single-particle cryo-EM have enabled the structural determination of macromolecular complexes at atomic resolution, particle orientation bias (the 'preferred' orientation problem) remains a complication for most specimens. Existing ...
Our brain undergoes significant micro- and macroscopic changes throughout its life cycle. It is therefore crucial to understand the effect of aging on the mechanical properties of the brain in order to develop accurate personalized simulations and di...
BACKGROUND: The identification and measurement of aortic aneurysms is an important clinical problem. While specialized high-resolution 3D CMR sequences allow detailed aortic assessment, they are time-consuming which limits their use in screening rout...
Computer methods and programs in biomedicine
Aug 22, 2024
BACKGROUND: Material characterization of brain white matter (BWM) is difficult due to the anisotropy inherent to the three-dimensional microstructure and the various interactions between heterogeneous brain-tissue (axon, myelin, and glia). Developing...
. Diffusion tensor imaging (DTI) is excellent for non-invasively quantifying tissue microstructure. Theoretically DTI can be achieved with six different diffusion weighted images and one reference image, but the tensor estimation accuracy is poor in ...
BACKGROUND: Spatial mapping of transcriptional states provides valuable biological insights into cellular functions and interactions in the context of the tissue. Accurate 3D cell segmentation is a critical step in the analysis of this data towards u...
Various deep learning methods have recently been used for low dose CT (LDCT) denoising. Aggressive denoising may destroy the edge and fine anatomical structures of CT images. Therefore a key issue in LDCT denoising tasks is the difficulty of balancin...
We present a test technique and an accompanying computational framework to obtain data-driven, surrogate constitutive models that capture the response of isotropic, elastic-plastic materials loaded in-plane stress by combined normal and shear stresse...
Three-dimensional mesh post-processing is an important task because low-precision hardware and a poor capture environment will inevitably lead to unordered point clouds with unwanted noise and holes that should be suitably corrected while preserving ...
Advanced science (Weinheim, Baden-Wurttemberg, Germany)
Aug 4, 2022
Owing to programmable nonlinear dynamics, magnetic domain wall (DW)-based devices can be configured to function as spintronic neurons, promising to execute sophisticated tasks as a human brain. Developing energy-efficient, CMOS compatible, reliable, ...
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