AIMC Topic: Antibodies

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Machine learning for functional protein design.

Nature biotechnology Feb 15, 2024
Recent breakthroughs in AI coupled with the rapid accumulation of protein sequence and structure data have radically transformed computational protein design. New methods promise to escape the constraints of natural and laboratory evolution, accelera...
Biotechnology Antibodies Amino Acid Sequence Machine Learning Proteins
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Revolutionizing Synthetic Antibody Design: Harnessing Artificial Intelligence and Deep Sequencing Big Data for Unprecedented Advances.

Molecular biotechnology Feb 3, 2024
Synthetic antibodies (Abs) represent a category of engineered proteins meticulously crafted to replicate the functions of their natural counterparts. Such Abs are generated in vitro, enabling advanced molecular alterations associated with antigen rec...
Humans Antibodies High-Throughput Nucleotide Sequencing Protein Engineering Artificial Intelligence Big Data
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Applicability of Spatial Technology in Cancer Research.

Cancer research and treatment Jan 30, 2024
This review explores spatial mapping technologies in cancer research, highlighting their crucial role in understanding the complexities of the tumor microenvironment (TME). The TME, which is an intricate ecosystem of diverse cell types, has a signifi...
Humans Antibodies Research Personnel Research Neoplasms Artificial Intelligence Technology
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Anti-infliximab antibodies and low infliximab levels correlate with drug discontinuation in pediatric inflammatory bowel disease.

Journal of pediatric gastroenterology and nutrition Dec 27, 2023
BACKGROUND: Infliximab (IFX) use is limited by loss of response often due to the development of anti-IFX antibodies and low drug levels.
Young Adult Infliximab Immunologic Factors Inflammatory Bowel Diseases Drug Monitoring Gastrointestinal Agents Adolescent Crohn Disease Antibodies Humans Female Child Prospective Studies Colitis, Ulcerative
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Mpox (formerly monkeypox): pathogenesis, prevention, and treatment.

Signal transduction and targeted therapy Dec 27, 2023
In 2022, a global outbreak of Mpox (formerly monkeypox) occurred in various countries across Europe and America and rapidly spread to more than 100 countries and regions. The World Health Organization declared the outbreak to be a public health emerg...
Humans Artificial Intelligence Antibodies Mpox, Monkeypox Disease Outbreaks Antiviral Agents
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Effectiveness of strategies to suppress antibodies to infliximab in pediatric inflammatory bowel disease.

Journal of pediatric gastroenterology and nutrition Dec 5, 2023
OBJECTIVES: Antibodies to infliximab (ATIs) are associated with loss of response in children with inflammatory bowel disease (IBD). We aimed to describe the effectiveness of strategies for treatment modification following ATI development in pediatric...
Gastrointestinal Agents Tumor Necrosis Factor Inhibitors Antibodies Infliximab Retrospective Studies Humans Child Inflammatory Bowel Diseases
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DG-Affinity: predicting antigen-antibody affinity with language models from sequences.

BMC bioinformatics Nov 13, 2023
BACKGROUND: Antibody-mediated immune responses play a crucial role in the immune defense of human body. The evolution of bioengineering has led the progress of antibody-derived drugs, showing promising efficacy in cancer and autoimmune disease therap...
Antibodies Antibody Affinity Humans Neural Networks, Computer
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Computational Methods in Immunology and Vaccinology: Design and Development of Antibodies and Immunogens.

Journal of chemical theory and computation Aug 1, 2023
The design of new biomolecules able to harness immune mechanisms for the treatment of diseases is a prime challenge for computational and simulative approaches. For instance, in recent years, antibodies have emerged as an important class of therapeut...
Epitopes Vaccinology Computational Biology Antibodies Artificial Intelligence Computer Simulation Humans
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ImmuneBuilder: Deep-Learning models for predicting the structures of immune proteins.

Communications biology May 29, 2023
Immune receptor proteins play a key role in the immune system and have shown great promise as biotherapeutics. The structure of these proteins is critical for understanding their antigen binding properties. Here, we present ImmuneBuilder, a set of de...
Receptors, Antigen, T-Cell Models, Molecular Single-Domain Antibodies Antibodies Deep Learning
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Fast, accurate antibody structure prediction from deep learning on massive set of natural antibodies.

Nature communications Apr 25, 2023
Antibodies have the capacity to bind a diverse set of antigens, and they have become critical therapeutics and diagnostic molecules. The binding of antibodies is facilitated by a set of six hypervariable loops that are diversified through genetic rec...
Deep Learning Antibodies Complementarity Determining Regions Protein Conformation Antigens
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