Pacific Symposium on Biocomputing. Pacific Symposium on Biocomputing
Jan 1, 2023
Accurate prediction of TCR binding affinity to a target antigen is important for development of immunotherapy strategies. Recent computational methods were built on various deep neural networks and used the evolutionary-based distance matrix BLOSUM t...
Pacific Symposium on Biocomputing. Pacific Symposium on Biocomputing
Jan 1, 2023
Several biomedical applications contain multiple treatments from which we want to estimate the causal effect on a given outcome. Most existing Causal Inference methods, however, focus on single treatments. In this work, we propose a neural network th...
Pacific Symposium on Biocomputing. Pacific Symposium on Biocomputing
Jan 1, 2023
Precision medicine requires a deep understanding of complex biomedical and healthcare data, which is being generated at exponential rates and increasingly made available through public biobanks, electronic medical record systems and biomedical databa...
Pacific Symposium on Biocomputing. Pacific Symposium on Biocomputing
Jan 1, 2023
Identifying effective target-disease associations (TDAs) can alleviate the tremendous cost incurred by clinical failures of drug development. Although many machine learning models have been proposed to predict potential novel TDAs rapidly, their cred...
Pacific Symposium on Biocomputing. Pacific Symposium on Biocomputing
Jan 1, 2023
Although protein sequence data is growing at an ever-increasing rate, the protein universe is still sparsely annotated with functional and structural annotations. Computational approaches have become efficient solutions to infer annotations for unlab...
MOTIVATION: Over 300 000 protein-protein interaction (PPI) pairs have been identified in the human proteome and targeting these is fast becoming the next frontier in drug design. Predicting PPI sites, however, is a challenging task that traditionally...
MOTIVATION: Protein essentiality is usually accepted to be a conditional trait and strongly affected by cellular environments. However, existing computational methods often do not take such characteristics into account, preferring to incorporate all ...
Methods in molecular biology (Clifton, N.J.)
Jan 1, 2023
Today, -omics analyses, including the systematic cataloging of messenger RNA and microRNA sequences or DNA methylation patterns in a cell population, organ or tissue sample, allow for an unbiased, comprehensive genome-level analysis of complex diseas...
Methods in molecular biology (Clifton, N.J.)
Jan 1, 2023
Protein interactions play a critical role in all biological processes, but experimental identification of protein interactions is a time- and resource-intensive process. The advances in next-generation sequencing and multi-omics technologies have gre...
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