AIMC Topic: Nucleic Acids

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Nucleic acid spheres for treating capillarisation of liver sinusoidal endothelial cells in liver fibrosis.

Nature communications May 15, 2025
Liver sinusoidal endothelial cells (LSECs) lose their characteristic fenestrations and become capillarized during the progression of liver fibrosis. Mesenchymal stem cell (MSC) transplantation can reverse this capillarization and reduce fibrosis, but...
Liver Cirrhosis Disease Models, Animal Mice, Inbred C57BL Mice Nanoparticles Nucleic Acids Endothelial Cells Mesenchymal Stem Cell Transplantation Animals Male Humans MicroRNAs Liver Mesenchymal Stem Cells
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Advances in artificial intelligence-envisioned technologies for protein and nucleic acid research.

Drug discovery today Apr 17, 2025
Artificial intelligence (AI) and machine learning (ML) have revolutionized pharmaceutical research, particularly in protein and nucleic acid studies. This review summarizes the current status of AI and ML applications in the pharmaceutical sector, fo...
Humans Artificial Intelligence Proteins Nucleic Acids Animals Machine Learning Drug Discovery Precision Medicine Drug Development
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Deciphering Protein Secondary Structures and Nucleic Acids in Cryo-EM Maps Using Deep Learning.

Journal of chemical information and modeling Jan 21, 2025
With the resolution revolution of cryo-electron microscopy (cryo-EM) and the rapid development of image processing technology, cryo-EM has become an indispensable experimental method for determining the three-dimensional structures of biological macr...
Deep Learning Proteins Models, Molecular Protein Structure, Secondary Nucleic Acids Cryoelectron Microscopy
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Machine Learning-Assisted, Dual-Channel CRISPR/Cas12a Biosensor-In-Microdroplet for Amplification-Free Nucleic Acid Detection for Food Authenticity Testing.

ACS nano Dec 2, 2024
The development of novel detection technology for meat species authenticity is imperative. Here, we developed a machine learning-supported, dual-channel biosensor-in-microdroplet platform for meat species authenticity detection named CC-drop (RISPR/C...
CRISPR-Associated Proteins Nucleic Acids Food Analysis Machine Learning Meat Animals Biosensing Techniques Bacterial Proteins CRISPR-Cas Systems Endodeoxyribonucleases
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AI-empowered visualization of nucleic acid testing.

Life sciences Oct 31, 2024
AIMS: The visualization of nucleic acid testing (NAT) results plays a critical role in diagnosing and monitoring infectious and genetic diseases. The review aims to review the current status of AI-based NAT result visualization. It systematically int...
Nucleic Acid Amplification Techniques Nucleic Acids Artificial Intelligence Algorithms Humans
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SOFB is a comprehensive ensemble deep learning approach for elucidating and characterizing protein-nucleic-acid-binding residues.

Communications biology Jun 3, 2024
Proteins and nucleic-acids are essential components of living organisms that interact in critical cellular processes. Accurate prediction of nucleic acid-binding residues in proteins can contribute to a better understanding of protein function. Howev...
Nucleic Acids Protein Binding Binding Sites Computational Biology Deep Learning Proteins
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Accurate structure prediction of biomolecular interactions with AlphaFold 3.

Nature May 8, 2024
The introduction of AlphaFold 2 has spurred a revolution in modelling the structure of proteins and their interactions, enabling a huge range of applications in protein modelling and design. Here we describe our AlphaFold 3 model with a substantially...
Antibodies Ions Nucleic Acids Protein Conformation Ligands Protein Binding Proteins Models, Molecular Molecular Docking Simulation Humans Antigens Deep Learning Software Reproducibility of Results
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DeePNAP: A Deep Learning Method to Predict Protein-Nucleic Acid Binding Affinity from Their Sequences.

Journal of chemical information and modeling Mar 8, 2024
Predicting the protein-nucleic acid (PNA) binding affinity solely from their sequences is of paramount importance for the experimental design and analysis of PNA interactions (PNAIs). A large number of currently developed models for binding affinity ...
Deep Learning Protein Binding Proteins Mutation Nucleic Acids
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Mesophilic Argonaute-Mediated Polydisperse Droplet Biosensor for Amplification-Free, One-Pot, and Multiplexed Nucleic Acid Detection Using Deep Learning.

Analytical chemistry Jan 23, 2024
Detection of nucleic acids from a single multiplexed and amplification-free test is critical for ensuring food safety, clinical diagnostics, and environmental monitoring. In this study, we introduced a mesophilic Argonaute protein from (CbAgo), whic...
Nucleic Acids Argonaute Proteins Deep Learning Nucleic Acid Amplification Techniques Biosensing Techniques DNA
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Simple and Multiplexed Detection of Nucleic Acid Targets Based on Fluorescent Ring Patterns and Deep Learning Analysis.

ACS applied materials & interfaces Nov 16, 2023
Simple diagnostic tests for nucleic acid targets can provide great advantages for applications such as rapid pathogen detection. Here, we developed a membrane assay for multiplexed detection of nucleic acid targets based on the visualization of two-d...
Oligonucleotide Probes Nucleic Acid Amplification Techniques Fluorescent Dyes Nucleic Acids SARS-CoV-2 Deep Learning
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