AIMC Topic: Cryptosporidium parvum

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E-pharmacophore and deep learning based high throughput virtual screening for identification of CDPK1 inhibitors of Cryptosporidium parvum.

Computational biology and chemistry Aug 13, 2024
Cryptosporidiosis, a prevalent gastrointestinal illness worldwide, is caused by the protozoan parasite Cryptosporidium parvum. Calcium-dependent protein kinase 1 (CpCDPK1), crucial for the parasite's life cycle, serves as a promising drug target due ...
Molecular Docking Simulation Deep Learning Molecular Structure Drug Evaluation, Preclinical Protein Kinases High-Throughput Screening Assays Antiprotozoal Agents Protein Kinase Inhibitors Cryptosporidium parvum Pharmacophore
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QSAR and deep learning model for virtual screening of potential inhibitors against Inosine 5' Monophosphate dehydrogenase (IMPDH) of Cryptosporidium parvum.

Journal of molecular graphics & modelling Dec 10, 2021
Cryptosporidium parvum (Cp) causes a gastro-intestinal disease called Cryptosporidiosis. C. parvum Inosine 5' monophosphate dehydrogenase (CpIMPDH) is responsible for the production of guanine nucleotides. In the present study, 37 known urea-based co...
Humans Molecular Docking Simulation Deep Learning Enzyme Inhibitors Quantitative Structure-Activity Relationship IMP Dehydrogenase Inosine Cryptosporidium Cryptosporidiosis Cryptosporidium parvum
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