AIMC Topic: Inosine

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QSAR and deep learning model for virtual screening of potential inhibitors against Inosine 5' Monophosphate dehydrogenase (IMPDH) of Cryptosporidium parvum.

Journal of molecular graphics & modelling Dec 10, 2021
Cryptosporidium parvum (Cp) causes a gastro-intestinal disease called Cryptosporidiosis. C. parvum Inosine 5' monophosphate dehydrogenase (CpIMPDH) is responsible for the production of guanine nucleotides. In the present study, 37 known urea-based co...
Humans Molecular Docking Simulation Deep Learning Enzyme Inhibitors Quantitative Structure-Activity Relationship IMP Dehydrogenase Inosine Cryptosporidium Cryptosporidiosis Cryptosporidium parvum
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EPAI-NC: Enhanced prediction of adenosine to inosine RNA editing sites using nucleotide compositions.

Analytical biochemistry Jan 18, 2019
RNA editing process like Adenosine to Intosine (A-to-I) often influences basic functions like splicing stability and most importantly the translation. Thus knowledge about editing sites is of great importance in molecular biology. With the growth of ...
Machine Learning User-Computer Interface ROC Curve Area Under Curve RNA Adenosine Inosine RNA Editing
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Dynamic regulation of RNA editing in human brain development and disease.

Nature neuroscience Jun 27, 2016
RNA editing is increasingly recognized as a molecular mechanism regulating RNA activity and recoding proteins. Here we surveyed the global landscape of RNA editing in human brain tissues and identified three unique patterns of A-to-I RNA editing rate...
Humans Brain RNA-Binding Proteins Gene Ontology Diagnosis Adenosine Adenosine Deaminase Inosine RNA Editing
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