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Drug Elimination Routes

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Prediction of Total Drug Clearance in Humans Using Animal Data: Proposal of a Multimodal Learning Method Based on Deep Learning.

Journal of pharmaceutical sciences 33497658
Research into pharmacokinetics plays an important role in the development process of new drugs. Accurately predicting human pharmacokinetic parameters from preclinical data can increase the success rate of clinical trials. Since clearance (CL) which ...
Animals Deep Learning Drug Discovery Drug Elimination Routes Humans Metabolic Clearance Rate Models, Biological Pharmaceutical Preparations Pharmacokinetics Rats Species Specificity
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Predicting Total Drug Clearance and Volumes of Distribution Using the Machine Learning-Mediated Multimodal Method through the Imputation of Various Nonclinical Data.

Journal of chemical information and modeling 35993595
Pharmacokinetic research plays an important role in the development of new drugs. Accurate predictions of human pharmacokinetic parameters are essential for the success of clinical trials. Clearance (CL) and volume of distribution (Vd) are important ...
Animals Drug Elimination Routes Humans Machine Learning Models, Biological Pharmaceutical Preparations
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