AIMC Topic: Everolimus

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Integrated transcriptomic and functional modeling reveals AKT and mTOR synergy in colorectal cancer.

Scientific reports
Colorectal cancer (CRC) treatment remains challenging due to genetic heterogeneity and resistance mechanisms. To address this, we developed a drug discovery pipeline using patient-derived primary CRC cultures with diverse genomic profiles. These cult...

Everolimus in heavily pretreated metastatic breast cancer: Is real world experience different?

Indian journal of cancer
BACKGROUND: Drugs targeting mammalian target of rapamycin signaling pathway have been recently approved for treatment of hormone receptor (HR) positive metastatic breast cancer (MBC). However, there is lack of real world data from India on the use of...