AIMC Topic: Homogentisate 1,2-Dioxygenase

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Redefining a new frontier in alkaptonuria therapy with AI-driven drug candidate design via innovation.

Zeitschrift fur Naturforschung. C, Journal of biosciences Jul 12, 2024
A rare metabolic condition called alkaptonuria (AKU) is caused by a decrease in homogentisate 1,2 dioxygenase (HGO) activity due to a mutation in homogentisate dioxygenase (HGD) gene. Homogentisic acid is a byproduct of the catabolism of tyrosine and...
Humans Artificial Intelligence Computer Simulation Molecular Docking Simulation Drug Design Flavanones Enzyme Inhibitors Kaempferols Cyclohexanones Alkaptonuria Homogentisate 1,2-Dioxygenase 4-Hydroxyphenylpyruvate Dioxygenase Nitrobenzoates Homogentisic Acid
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Machine learning application for patient stratification and phenotype/genotype investigation in a rare disease.

Briefings in bioinformatics Sep 2, 2021
Alkaptonuria (AKU, OMIM: 203500) is an autosomal recessive disorder caused by mutations in the Homogentisate 1,2-dioxygenase (HGD) gene. A lack of standardized data, information and methodologies to assess disease severity and progression represents ...
Humans Machine Learning Precision Medicine Female Male Genotype Databases, Genetic Mutation Patient Selection Rare Diseases Alkaptonuria Homogentisate 1,2-Dioxygenase
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