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Myosins

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Deep learning the structural determinants of protein biochemical properties by comparing structural ensembles with DiffNets.

Nature communications
Understanding the structural determinants of a protein's biochemical properties, such as activity and stability, is a major challenge in biology and medicine. Comparing computer simulations of protein variants with different biochemical properties is...

Resilience of hierarchical actuators highlighted by a myosin-to-muscle mock-up.

Bioinspiration & biomimetics
Skeletal muscle is the main actuator of various families of vertebrates (mammals, fish, reptiles). It displays remarkable robustness to micro-damage, that supposedly originates both from its redundant hierarchical structure and its nervous command. A...