Edited by Luonan Chen Whereas biochemical markers are available for most types of cell death, current studies on non-autonomous cell death by entosis rely strictly on the identification of cell-in-cell structures (CICs), a unique morphological readou...
Non-interferometric quantitative phase imaging based on Transport of Intensity Equation (TIE) has been widely used in bio-medical imaging. However, analytic TIE phase retrieval is prone to low-spatial frequency noise amplification, which is caused by...
Instantaneous photosynthetically available radiation (IPAR) at the ocean surface and its vertical profile below the surface play a critical role in models to calculate net primary productivity of marine phytoplankton. In this work, we report two IPAR...
Emerging evidence suggests that circular RNA (circRNA) is an important regulator of a variety of pathological processes and serves as a promising biomarker for many complex human diseases. Nevertheless, there are relatively few known circRNA-disease ...
With the development of research on the complex aetiology of many diseases, computational drug repositioning methodology has proven to be a shortcut to costly and inefficient traditional methods. Therefore, developing more promising computational met...
MOTIVATION: Discovering the drug-target interactions (DTIs) is a crucial step in drug development such as the identification of drug side effects and drug repositioning. Since identifying DTIs by web-biological experiments is time-consuming and costl...
Breast cancer patients often have recurrence and metastasis after surgery. Predicting the risk of recurrence and metastasis for a breast cancer patient is essential for the development of precision treatment. In this study, we proposed a novel multi-...
Identifying synergistic drug combinations (SDCs) is a great challenge due to the combinatorial complexity and the fact that SDC is cell line specific. The existing computational methods either did not consider the cell line specificity of SDC, or did...
Accurate prediction of molecular properties, such as physicochemical and bioactive properties, as well as ADME/T (absorption, distribution, metabolism, excretion and toxicity) properties, remains a fundamental challenge for molecular design, especial...
Despite the modern advances in the available computational resources, the length and time scales of the physical systems that can be studied in full atomic detail, via molecular simulations, are still limited. To overcome such limitations, coarse-gra...
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