Journal of chemical information and modeling
39686716
Numerous studies show that circular RNA (circRNA) functions as a sponge for microRNA (miRNA), significantly regulating gene expression by interacting with miRNA, which in turn affects the progression of human diseases. Traditional experimental approa...
Circular RNAs in extracellular vesicles (EV-circRNAs) are gaining recognition as potential biomarkers for the diagnosis of gastric cancer (GC). Most current research is focused on identifying new biomarkers and their functional significance in diseas...
While ultrasonography effectively diagnoses Hashimoto's thyroiditis (HT), exploring its transcriptomic landscape could reveal valuable insights into disease mechanisms. This study aimed to identify HT-associated RNA signatures and investigate their p...
International journal of biological macromolecules
40023417
As our understanding of Circular RNAs (circRNAs) continues to expand, accumulating evidence has demonstrated that circRNAs can interact with microRNAs and RNA-binding proteins to modulate gene expression. More importantly, a subset of circRNAs has be...
International journal of molecular sciences
40003977
The prediction of circular RNA (circRNA)-drug associations plays a crucial role in understanding disease mechanisms and identifying potential therapeutic targets. Traditional methods often struggle to cope with the complexity of heterogeneous network...
Circular RNAs (circRNAs) have attracted increasing attention for their roles in human diseases, making the prediction of circRNA-disease associations (CDAs) a critical research area for advancing disease diagnosis and treatment. However, traditional ...
Journal of chemical information and modeling
39937612
In the emerging field of RNA drugs, circular RNA (circRNA) has attracted much attention as a novel multifunctional therapeutic target. Delving deeper into the intricate interactions between circRNA and disease is critical for driving drug discovery e...
BACKGROUND: RNA-binding proteins (RBPs) play crucial roles in many biological processes, and computationally identifying RNA-RBP interactions provides insights into the biological mechanism of diseases associated with RBPs.
BACKGROUND: Numerous studies have shown that circRNA can act as a miRNA sponge, competitively binding to miRNAs, thereby regulating gene expression and disease progression. Due to the high cost and time-consuming nature of traditional wet lab experim...
BACKGROUND: Different expression levels of circular RNAs (circRNAs) affect the sensitivity of human cells to drugs, thus producing different responses to the therapeutic effects of drugs. Using traditional biomedical experiments to discover and confi...