AIMC Topic: Neurofibromin 1

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A machine learning classifier trained on cancer transcriptomes detects NF1 inactivation signal in glioblastoma.

BMC genomics
BACKGROUND: We have identified molecules that exhibit synthetic lethality in cells with loss of the neurofibromin 1 (NF1) tumor suppressor gene. However, recognizing tumors that have inactivation of the NF1 tumor suppressor function is challenging be...

The Role of Artificial Intelligence in Identifying Gene Variants and Improving Diagnosis.

Genes
Neurofibromatosis type 1 (NF1) is an autosomal dominant disorder caused by mutations in the gene, typically diagnosed during early childhood and characterized by significant phenotypic heterogeneity. Despite advancements in next-generation sequencin...