AIMC Topic: Orphan Nuclear Receptors

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Mechanism of liver X receptor α and ATP binding cassette transporter A1 involved in preeclampsia using an optimized deep learning model.

European review for medical and pharmacological sciences Jul 1, 2023
OBJECTIVE: Preeclampsia (PE) is a complex disease-causing multisystem damage. Many genes, environmental factors, and their interactions are involved in the development and progression of PE. The pathogenesis of PE is not fully understood, limiting th...
Humans Female Deep Learning RNA, Messenger Pre-Eclampsia Cholesterol, HDL ATP-Binding Cassette Transporters ATP Binding Cassette Transporter 1 Liver X Receptors Orphan Nuclear Receptors
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Predicting selective liver X receptor β agonists using multiple machine learning methods.

Molecular bioSystems May 1, 2015
Liver X receptor (LXR) α and β are cholesterol sensors; they respond to excess cholesterol and stimulate reverse cholesterol transport. Activating LXRs represents a promising therapeutic option for dyslipidemia. However, activating LXRα may cause unw...
Humans Machine Learning Algorithms Reproducibility of Results Drug Discovery Protein Binding Models, Theoretical Liver X Receptors Orphan Nuclear Receptors
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