AIMC Topic: Liver X Receptors

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Exposure to nitrate induces alterations in blood parameter responses, liver immunity, and lipid metabolism in juvenile turbot (Scophthalmus maximus).

Aquatic toxicology (Amsterdam, Netherlands) Aug 24, 2022
Nitrate (NO) pollution of waterbodies has attracted significant global attention as it poses a serious threat to aquatic organisms and human beings. This study aimed to evaluate the role of NO, an end product of biological nitrification processes, in...
Humans Tumor Necrosis Factor-alpha Animals RNA, Messenger Water Pollutants, Chemical Liver Lipid Metabolism Heat-Shock Proteins Nitrates Alanine Transaminase Aspartate Aminotransferases Immunoglobulin M Complement C3 Fish Proteins Peroxisome Proliferator-Activated Receptors Carnitine O-Palmitoyltransferase Sterol Regulatory Element Binding Protein 1 Flatfishes Complement C4 Liver X Receptors Muramidase
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Mechanism of liver X receptor α and ATP binding cassette transporter A1 involved in preeclampsia using an optimized deep learning model.

European review for medical and pharmacological sciences Jul 1, 2023
OBJECTIVE: Preeclampsia (PE) is a complex disease-causing multisystem damage. Many genes, environmental factors, and their interactions are involved in the development and progression of PE. The pathogenesis of PE is not fully understood, limiting th...
Humans Female Deep Learning RNA, Messenger Pre-Eclampsia Cholesterol, HDL ATP-Binding Cassette Transporters ATP Binding Cassette Transporter 1 Liver X Receptors Orphan Nuclear Receptors
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Predicting selective liver X receptor β agonists using multiple machine learning methods.

Molecular bioSystems May 1, 2015
Liver X receptor (LXR) α and β are cholesterol sensors; they respond to excess cholesterol and stimulate reverse cholesterol transport. Activating LXRs represents a promising therapeutic option for dyslipidemia. However, activating LXRα may cause unw...
Humans Machine Learning Algorithms Reproducibility of Results Drug Discovery Protein Binding Models, Theoretical Liver X Receptors Orphan Nuclear Receptors
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