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Liver X Receptors

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Exposure to nitrate induces alterations in blood parameter responses, liver immunity, and lipid metabolism in juvenile turbot (Scophthalmus maximus).

Aquatic toxicology (Amsterdam, Netherlands) 36041359
Nitrate (NO) pollution of waterbodies has attracted significant global attention as it poses a serious threat to aquatic organisms and human beings. This study aimed to evaluate the role of NO, an end product of biological nitrification processes, in...
Alanine Transaminase Animals Aspartate Aminotransferases Carnitine O-Palmitoyltransferase Complement C3 Complement C4 Fish Proteins Flatfishes Heat-Shock Proteins Humans Immunoglobulin M Lipid Metabolism Liver Liver X Receptors Muramidase Nitrates Peroxisome Proliferator-Activated Receptors RNA, Messenger Sterol Regulatory Element Binding Protein 1 Tumor Necrosis Factor-alpha Water Pollutants, Chemical
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Predicting selective liver X receptor β agonists using multiple machine learning methods.

Molecular bioSystems 25734698
Liver X receptor (LXR) α and β are cholesterol sensors; they respond to excess cholesterol and stimulate reverse cholesterol transport. Activating LXRs represents a promising therapeutic option for dyslipidemia. However, activating LXRα may cause unw...
Algorithms Drug Discovery Humans Liver X Receptors Machine Learning Models, Theoretical Orphan Nuclear Receptors Protein Binding Reproducibility of Results
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Mechanism of liver X receptor α and ATP binding cassette transporter A1 involved in preeclampsia using an optimized deep learning model.

European review for medical and pharmacological sciences 37458649
OBJECTIVE: Preeclampsia (PE) is a complex disease-causing multisystem damage. Many genes, environmental factors, and their interactions are involved in the development and progression of PE. The pathogenesis of PE is not fully understood, limiting th...
ATP Binding Cassette Transporter 1 ATP-Binding Cassette Transporters Cholesterol, HDL Deep Learning Female Humans Liver X Receptors Orphan Nuclear Receptors Pre-Eclampsia RNA, Messenger
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