AIMC Topic: ATP-Binding Cassette Transporters

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Utilizing Machine Learning to Identify Biomarkers of Endoplasmic Reticulum Stress and Analyze Immune Cell Infiltration in Parkinson's Disease.

Molecular neurobiology Mar 23, 2024
The neurodegenerative disorder known as Parkinson's disease (PD) affects many people. The objective of this investigation was to examine the relationship between immune system infiltration, ATP-binding cassette transporter subfamily A member 7 (ABCA7...
Parkinson Disease Humans Endoplasmic Reticulum Stress Machine Learning ATP-Binding Cassette Transporters Biomarkers
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Benchmarking deep learning splice prediction tools using functional splice assays.

Human mutation May 20, 2021
Hereditary disorders are frequently caused by genetic variants that affect pre-messenger RNA splicing. Though genetic variants in the canonical splice motifs are almost always disrupting splicing, the pathogenicity of variants in the noncanonical spl...
Introns RNA Splicing RNA Splice Sites Mutation Benchmarking ATP-Binding Cassette Transporters Humans Deep Learning
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Prediction of causative genes in inherited retinal disorder from fundus photography and autofluorescence imaging using deep learning techniques.

The British journal of ophthalmology Apr 20, 2021
BACKGROUND/AIMS: To investigate the utility of a data-driven deep learning approach in patients with inherited retinal disorder (IRD) and to predict the causative genes based on fundus photography and fundus autofluorescence (FAF) imaging.
Retinal Diseases ATP-Binding Cassette Transporters Fluorescein Angiography Rod Cell Outer Segment Female Follow-Up Studies Aged Fundus Oculi Algorithms Aged, 80 and over Eye Proteins Humans Prognosis Male Retrospective Studies Middle Aged Deep Learning Young Adult Adult Adolescent Child
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Changes in the expression of four ABC transporter genes in response to imidacloprid in Bemisia tabaci Q (Hemiptera: Aleyrodidae).

Pesticide biochemistry and physiology Nov 20, 2018
Bemisia tabaci (Gennadius) (Hemiptera: Aleyrodidae), a globally invasive species complex that causes serious damage to field crops, has developed resistance to imidacloprid and many other pesticides. Insect detoxify to pesticides may partially depend...
Thorax Head Insect Proteins Abdomen ATP-Binding Cassette Transporters Female Neonicotinoids Hemiptera Insecticides Animals Nitro Compounds Male Gene Expression Regulation
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Combined bioinformatics and machine learning methodologies reveal prognosis-related ceRNA network and propose ABCA8, CAT, and CXCL12 as independent protective factors against osteosarcoma.

Advances in clinical and experimental medicine : official organ Wroclaw Medical University Aug 1, 2024
BACKGROUND: Aberrant circular RNA (circRNA) acts as an oncogene or suppressor during neoplasm initiation and development. However, the functions of most circRNAs in osteosarcoma (OS) remain unclear.
RNA, Messenger Gene Expression Regulation, Neoplastic Osteosarcoma Biomarkers, Tumor Gene Regulatory Networks Computational Biology ATP-Binding Cassette Transporters RNA, Circular Humans Protective Factors Machine Learning RNA, Competitive Endogenous Prognosis Bone Neoplasms MicroRNAs Chemokine CXCL12
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Mechanism of liver X receptor α and ATP binding cassette transporter A1 involved in preeclampsia using an optimized deep learning model.

European review for medical and pharmacological sciences Jul 1, 2023
OBJECTIVE: Preeclampsia (PE) is a complex disease-causing multisystem damage. Many genes, environmental factors, and their interactions are involved in the development and progression of PE. The pathogenesis of PE is not fully understood, limiting th...
RNA, Messenger Pre-Eclampsia Cholesterol, HDL ATP-Binding Cassette Transporters Humans Female Deep Learning ATP Binding Cassette Transporter 1 Liver X Receptors Orphan Nuclear Receptors
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Association of ATP-Binding Cassette Transporter (ABC) Gene Polymorphisms with Viral Load in Patients with Genotype 1 Hepatitis C Virus Infection.

Clinical laboratory Sep 1, 2016
BACKGROUND: ATP-binding cassette transporters (ABC) gene polymorphisms are associated with various biological functions, including hepatitis C virus (HCV) infection. This study aims to explore the impact of ABC transporters polymorphisms on HCV viral...
ATP Binding Cassette Transporter, Subfamily G, Member 2 ATP Binding Cassette Transporter, Subfamily G, Member 5 ATP Binding Cassette Transporter 1 ATP Binding Cassette Transporter, Subfamily B ATP Binding Cassette Transporter, Subfamily B, Member 11 Hepatitis C, Chronic Male Gene Frequency Middle Aged ATP-Binding Cassette Transporters Viral Load Humans Female Polymorphism, Single Nucleotide ATP Binding Cassette Transporter, Subfamily B, Member 1 Interleukins Hepacivirus Neoplasm Proteins Genotype Lipoproteins
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Classification of Breast Cancer Resistant Protein (BCRP) Inhibitors and Non-Inhibitors Using Machine Learning Approaches.

Combinatorial chemistry & high throughput screening Jan 1, 2015
The breast cancer resistant protein (BCRP) is an important transporter and its inhibitors play an important role in cancer treatment by improving the oral bioavailability as well as blood brain barrier (BBB) permeability of anticancer drugs. In this ...
Humans Neural Networks, Computer Machine Learning Neoplasm Proteins ATP-Binding Cassette Transporters ATP Binding Cassette Transporter, Subfamily G, Member 2
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