AIMC Topic: Penicillin-Binding Proteins

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Machine learning and cheminformatics-based Identification of lichen-derived compounds targeting mutant PBP4 in Staphylococcus aureus.

Molecular diversity Feb 15, 2025
Penicillin-binding protein 4 (PBP4) is essential in imparting significant β-lactam antibiotics resistance in Staphylococcus aureus (S. aureus) and the mutation R200L in PBP4 is linked to β-lactam non-susceptibility in natural strains, complicating tr...
Machine Learning Anti-Bacterial Agents Molecular Docking Simulation Staphylococcus aureus Bacterial Proteins Mutation Molecular Dynamics Simulation Lichens Cheminformatics Penicillin-Binding Proteins
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Accurate prediction of antimicrobial resistance and genetic marker of Staphylococcus aureus clinical isolates using MALDI-TOF MS and machine learning - across DRIAMS and Taiwan database.

International journal of antimicrobial agents Sep 6, 2024
BACKGROUND: The use of matrix-assisted laser desorption/ionisation-time-of-flight mass spectra (MALDI-TOF MS) with machine learning (ML) has been explored for predicting antimicrobial resistance. This study evaluates the effectiveness of MALDI-TOF MS...
Humans Machine Learning Anti-Bacterial Agents Drug Resistance, Bacterial Databases, Factual Microbial Sensitivity Tests Staphylococcus aureus Taiwan Bacterial Proteins Genetic Markers Staphylococcal Infections Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization Penicillin-Binding Proteins Oxacillin
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