AIMC Topic: Point Mutation

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DDMut: predicting effects of mutations on protein stability using deep learning.

Nucleic acids research Jul 5, 2023
Understanding the effects of mutations on protein stability is crucial for variant interpretation and prioritisation, protein engineering, and biotechnology. Despite significant efforts, community assessments of predictive tools have highlighted ongo...
Software Deep Learning Proteins Mutation Protein Stability Point Mutation
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FireProtDB: database of manually curated protein stability data.

Nucleic acids research Jan 8, 2021
The majority of naturally occurring proteins have evolved to function under mild conditions inside the living organisms. One of the critical obstacles for the use of proteins in biotechnological applications is their insufficient stability at elevate...
Machine Learning Software Computational Biology Proteins Databases, Protein Models, Molecular Internet Protein Stability Datasets as Topic Molecular Sequence Annotation Point Mutation
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Ensemble-Based Somatic Mutation Calling in Cancer Genomes.

Methods in molecular biology (Clifton, N.J.) Jan 1, 2020
Identification of somatic mutations in tumor tissue is challenged by both technical artifacts, diverse somatic mutational processes, and genetic heterogeneity in the tumors. Indeed, recent independent benchmark studies have revealed low concordance b...
Humans Software Neoplasms Genomics Polymorphism, Single Nucleotide Mutation Supervised Machine Learning Genome, Human INDEL Mutation Point Mutation
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