AIMC Topic: Protein Transport

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DeepMito: accurate prediction of protein sub-mitochondrial localization using convolutional neural networks.

Bioinformatics (Oxford, England)
MOTIVATION: The correct localization of proteins in cell compartments is a key issue for their function. Particularly, mitochondrial proteins are physiologically active in different compartments and their aberrant localization contributes to the path...

[Prediction of protein subcellular localization based on multilayer sparse coding].

Sheng wu gong cheng xue bao = Chinese journal of biotechnology
In order to provide a theoretical basis for better understanding the function and properties of proteins, we proposed a simple and effective feature extraction method for protein sequences to determine the subcellular localization of proteins. First,...

DeepSig: deep learning improves signal peptide detection in proteins.

Bioinformatics (Oxford, England)
MOTIVATION: The identification of signal peptides in protein sequences is an important step toward protein localization and function characterization.

pLoc-mHum: predict subcellular localization of multi-location human proteins via general PseAAC to winnow out the crucial GO information.

Bioinformatics (Oxford, England)
MOTIVATION: For in-depth understanding the functions of proteins in a cell, the knowledge of their subcellular localization is indispensable. The current study is focused on human protein subcellular location prediction based on the sequence informat...

Deep Forest-based Prediction of Protein Subcellular Localization.

Current gene therapy
MOTIVATION: Knowledge of the correct protein subcellular localization is necessary for understanding the function of a protein and revealing the mechanism of many human diseases due to protein subcellular mislocalization, which is required before app...

An introduction to deep learning on biological sequence data: examples and solutions.

Bioinformatics (Oxford, England)
MOTIVATION: Deep neural network architectures such as convolutional and long short-term memory networks have become increasingly popular as machine learning tools during the recent years. The availability of greater computational resources, more data...

DeepLoc: prediction of protein subcellular localization using deep learning.

Bioinformatics (Oxford, England)
MOTIVATION: The prediction of eukaryotic protein subcellular localization is a well-studied topic in bioinformatics due to its relevance in proteomics research. Many machine learning methods have been successfully applied in this task, but in most of...

HPSLPred: An Ensemble Multi-Label Classifier for Human Protein Subcellular Location Prediction with Imbalanced Source.

Proteomics
Predicting the subcellular localization of proteins is an important and challenging problem. Traditional experimental approaches are often expensive and time-consuming. Consequently, a growing number of research efforts employ a series of machine lea...

Protein subcellular localization prediction using multiple kernel learning based support vector machine.

Molecular bioSystems
Predicting the subcellular locations of proteins can provide useful hints that reveal their functions, increase our understanding of the mechanisms of some diseases, and finally aid in the development of novel drugs. As the number of newly discovered...

Hum-mPLoc 3.0: prediction enhancement of human protein subcellular localization through modeling the hidden correlations of gene ontology and functional domain features.

Bioinformatics (Oxford, England)
MOTIVATION: Protein subcellular localization prediction has been an important research topic in computational biology over the last decade. Various automatic methods have been proposed to predict locations for large scale protein datasets, where stat...