The Journal of chemical physics
Aug 7, 2020
Safe and efficient use of ultrasmall nanoparticles (NPs) in biomedicine requires numerous independent conditions to be met, including colloidal stability, selectivity for proteins and membranes, binding specificity, and low affinity for plasma protei...
Briefings in bioinformatics
Jul 15, 2020
Functional annotation of protein sequence with high accuracy has become one of the most important issues in modern biomedical studies, and computational approaches of significantly accelerated analysis process and enhanced accuracy are greatly desire...
Briefings in bioinformatics
Jul 15, 2020
A number of machine learning (ML)-based algorithms have been proposed for predicting mutation-induced stability changes in proteins. In this critical review, we used hypothetical reverse mutations to evaluate the performance of five representative al...
Nucleic acids research
Jul 2, 2020
MusiteDeep is an online resource providing a deep-learning framework for protein post-translational modification (PTM) site prediction and visualization. The predictor only uses protein sequences as input and no complex features are needed, which res...
Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference
Jul 1, 2020
DNA-Sequencing of tumor cells has revealed thousands of genetic mutations. However, cancer is caused by only some of them. Identifying mutations that contribute to tumor growth from neutral ones is extremely challenging and is currently carried out m...
Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference
Jul 1, 2020
Integration of multi-omics and pharmacological data can help researchers understand the impact of drugs on dynamic biological systems. Network-based approaches to such integration explore the interaction of different cellular components and drugs. Ho...
Bioinformatics (Oxford, England)
Jul 1, 2020
MOTIVATION: Protein model quality estimation, in many ways, informs protein structure prediction. Despite their tight coupling, existing model quality estimation methods do not leverage inter-residue distance information or the latest technological b...
Bioinformatics (Oxford, England)
Jun 1, 2020
MOTIVATION: Protein structural annotations (PSAs) are essential abstractions to deal with the prediction of protein structures. Many increasingly sophisticated PSAs have been devised in the last few decades. However, the need for annotations that are...
Briefings in bioinformatics
May 21, 2020
With the explosive growth of biological sequences generated in the post-genomic era, one of the most challenging problems in bioinformatics and computational biology is to computationally characterize sequences, structures and functions in an efficie...
Bioinformatics (Oxford, England)
May 1, 2020
MOTIVATION: Knowledge of protein-ligand binding residues is important for understanding the functions of proteins and their interaction mechanisms. From experimentally solved protein structures, how to accurately identify its potential binding sites ...