Protein-protein interactions (PPI) play a crucial role in numerous key biological processes, and the structure of protein complexes provides valuable clues for in-depth exploration of molecular-level biological processes. Protein-protein docking tech...
Interdisciplinary sciences, computational life sciences
Apr 3, 2024
With the rapid development of NGS technology, the number of protein sequences has increased exponentially. Computational methods have been introduced in protein functional studies because the analysis of large numbers of proteins through biological e...
Deciphering the relationship between a gene and its genomic context is fundamental to understanding and engineering biological systems. Machine learning has shown promise in learning latent relationships underlying the sequence-structure-function par...
Journal of chemical information and modeling
Mar 29, 2024
Water molecules are integral to the structural stability of proteins and vital for facilitating molecular interactions. However, accurately predicting their precise position around protein structures remains a significant challenge, making it a vibra...
Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy
Mar 28, 2024
This study investigates the challenges encountered in utilizing portable near-infrared (NIR) spectrometers in agriculture, specifically in developing predictive models with high accuracy and robust generalization abilities despite limited spectral re...
International journal of biological macromolecules
Mar 27, 2024
Phosphorylation modifications play important regulatory roles in most biological processes. However, the functional assignment for the vast majority of the identified phosphosites remains a major challenge. Here, we provide a deep learning framework ...
Proteins need to be located in appropriate spatiotemporal contexts to carry out their diverse biological functions. Mislocalized proteins may lead to a broad range of diseases, such as cancer and Alzheimer's disease. Knowing where a target protein re...
The fast motions of proteins at the picosecond to nanosecond timescale, known as fast dynamics, are closely related to protein conformational entropy and rearrangement, which in turn affect catalysis, ligand binding and protein allosteric effects. Th...
Scientists and security experts are concerned that the increasing power of AI-assisted protein design and synthesis could be abused by various actors for terrorist or criminal purposes. [Image: see text]
Understanding intracellular phase separation is crucial for deciphering transcriptional control, cell fate transitions, and disease mechanisms. However, the key residues, which impact phase separation the most for protein phase separation function ha...