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Discovery of Pyrazolo[3,4-]pyridazinone Derivatives as Selective DDR1 Inhibitors via Deep Learning Based Design, Synthesis, and Biological Evaluation.

Journal of medicinal chemistry 34821145
Alterations of discoidin domain receptor1 (DDR1) may lead to increased production of inflammatory cytokines, making DDR1 an attractive target for inflammatory bowel disease (IBD) therapy. A scaffold-based molecular design workflow was established and...
Animals Anti-Inflammatory Agents Colitis Deep Learning Dextran Sulfate Discoidin Domain Receptor 1 Drug Design Drug Discovery Drug Screening Assays, Antitumor Humans Mice Mice, Inbred C57BL Mice, Inbred ICR Molecular Structure Protein Kinase Inhibitors Pyrazolones Pyridazines
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