AIMC Topic: Mice, Inbred ICR
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TFEB/LAMP2 contributes to PM-induced autophagy-lysosome dysfunction and alpha-synuclein dysregulation in astrocytes.
Journal of environmental sciences (China)
Oct 5, 2023
Atmospheric particulate matter (PM) exacerbates the risk factor for Alzheimer's and Parkinson's diseases (PD) by promoting the alpha-synuclein (α-syn) pathology in the brain. However, the molecular mechanisms of astrocytes involvement in α-syn pathol...
Anti-Fatigue and Exercise Performance Improvement Effect of Extract in Mice.
Nutrients
Feb 27, 2022
(GT) is a native perennial plant growing across the coastline areas in Taiwan. The current study aimed to examine the efficacy of GT extract in ameliorating physical fatigue during exercise and increasing exercise performance. Fifty male Institute o...
The Anti-Adiposity Mechanisms of Ampelopsin and Vine Tea Extract in High Fat Diet and Alcohol-Induced Fatty Liver Mouse Models.
Molecules (Basel, Switzerland)
Jan 18, 2022
(AG) is an ancient medicinal plant that is mainly distributed and used in southwest China. It exerts therapeutic effects, such as antioxidant, anti-diabetic, and anti-inflammatory activities, reductions in blood pressure and cholesterol and hepatopr...
Discovery of Pyrazolo[3,4-]pyridazinone Derivatives as Selective DDR1 Inhibitors via Deep Learning Based Design, Synthesis, and Biological Evaluation.
Journal of medicinal chemistry
Nov 25, 2021
Alterations of discoidin domain receptor1 (DDR1) may lead to increased production of inflammatory cytokines, making DDR1 an attractive target for inflammatory bowel disease (IBD) therapy. A scaffold-based molecular design workflow was established and...
The Immunogenicity of the C Fragment of Tetanus Neurotoxin in Production of Tetanus Antitoxin.
BioMed research international
Dec 31, 2018
The demand of tetanus antitoxin (TAT) as tetanus treatment in developing and underdeveloped countries is still great since it is relatively easy to achieve and affordable. However, there are still issues in the preparation of highly effective TAT wit...
Machine learning-based prediction of adverse drug effects: An example of seizure-inducing compounds.
Journal of pharmacological sciences
Jan 28, 2017
Various biological factors have been implicated in convulsive seizures, involving side effects of drugs. For the preclinical safety assessment of drug development, it is difficult to predict seizure-inducing side effects. Here, we introduced a machin...
The injury of serotonin on intestinal epithelium cell renewal of weaned diarrhoea mice.
European journal of histochemistry : EJH
Dec 28, 2016
Diarrhoea is a common cause of death in children and weaned animals. Recent research has found that serotonin (5-HT) in the gastrointestinal tract plays an important role in regulating growth and the maintenance of mucosa, which protect against diarr...
Exposure to Aroclor-1254 impairs spindle assembly during mouse oocyte maturation.
Environmental toxicology
Jul 15, 2015
Polychlorinated biphenyls (PCBs), as typical environmental estrogen disruptors, are a structurally-related group of halogenated aromatic hydrocarbons that are composed of 209 isomers and present as a mixture in the environment. PCBs congener with dif...
Neuroprotective effects of Suhexiang Wan on the in vitro and in vivo models of Parkinson's disease.
Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan
Dec 1, 2019
OBJECTIVE: To examine the role of KSOP1009 (a modified formulation of Suhexiang Wan essential oil) in an animal model of Parkinson's disease (PD) induced by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) injection.
Renoprotective Effects of Shout Camphor Medicinal Mushroom (Taiwanofungus camphorates, Basidiomycetes) Mycelia on Several Media in Mice with Chronic Kidney Disease.
International journal of medicinal mushrooms
Jan 1, 2016
Taiwanofungus camphoratus has been widely used in Taiwan as a folk medicine to prevent and treat liver diseases, diarrhea, abdominal pain, itchy skin, and hypertension. Recent studies have shown that T. camphoratus mycelia extracts exert anti-inflamm...
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