AIMC Topic: Receptors, Interleukin-1 Type I

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Identification of IL1R1 as a potential key PANoptosis-related gene in myocardial ischemia-reperfusion injury using machine learning.

Scientific reports Nov 20, 2025
Myocardial ischemia-reperfusion injury (MIRI) involves multifaceted pathogenic mechanisms, including inflammatory responses, immune dysregulation, and emerging forms of programmed cell death such as PANoptosis. However, the precise regulatory genes l...
Humans Machine Learning Animals Male Molecular Docking Simulation Mice Disease Models, Animal Myocardial Reperfusion Injury Receptors, Interleukin-1 Type I
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Small molecule inhibitors of IL-1R1/IL-1β interaction identified via transfer machine learning QSAR modelling.

International journal of biological macromolecules Nov 7, 2024
The human interleukin-1 receptor I (IL-1R1) is a cytokine receptor recognized by interleukin 1β (IL-1β), among other cytokines. Over activation of IL-1R1 has been implicated in various inflammatory conditions. This research aims to identify small-mol...
Humans Machine Learning Molecular Docking Simulation Protein Binding Interleukin-1beta Molecular Dynamics Simulation Quantitative Structure-Activity Relationship Small Molecule Libraries Receptors, Interleukin-1 Type I
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