High-throughput deep mutational scanning (DMS) experiments have significantly impacted protein engineering, drug discovery, immunology, cancer biology, and evolutionary biology by enabling the systematic understanding of protein functions. However, t...
International journal of molecular sciences
Jul 17, 2023
During the outbreak of COVID-19, many SARS-CoV-2 variants presented key amino acid mutations that influenced their binding abilities with angiotensin-converting enzyme 2 (hACE2) and neutralizing antibodies. For the B.1.617 lineage, there had been fea...
Journal of biomolecular structure & dynamics
Jul 16, 2023
The latest variant of coronavirus is omicron. The World Health Organization (WHO) designated variation 'B.1.1.529' named omicron as a variant of concern (VOC) on 26 November 2021. By September 2020, it will have infected over 16 million patients and ...
Journal of biomolecular structure & dynamics
Jul 14, 2023
De novo generation of molecules with the necessary features offers a promising opportunity for artificial intelligence, such as deep generative approaches. However, creating novel compounds having biological activities toward two distinct targets con...
Biochemical and biophysical research communications
Jul 12, 2023
The recent outbreak of Corona Virus Disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has been a severe threat to the global public health and economy, however, effective drugs to treat COVID-19 are still ...
The COVID-19 pandemic has been adversely affecting the patient management systems in hospitals around the world. Radiological imaging, especially chest x-ray and lung Computed Tomography (CT) scans, plays a vital role in the severity analysis of hosp...
Journal of biomolecular structure & dynamics
Jun 24, 2023
Covid-19 is a global pandemic. Early and accurate detection of positive cases prevent the further spread of this epidemic and help to treat rapidly the infected patients. During the peak of this epidemic, there was an insufficiency of Covid-19 test k...
The COVID-19 pandemic has necessitated the development of reliable diagnostic methods for accurately detecting the novel coronavirus and its variants. Deep learning (DL) techniques have shown promising potential as screening tools for COVID-19 detect...
BACKGROUND: The medical profession is facing an excessive workload, which has led to the development of various Computer-Aided Diagnosis (CAD) systems as well as Mobile-Aid Diagnosis (MAD) systems. These technologies enhance the speed and accuracy of...