AI Medical Compendium Topic

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Spindle Apparatus

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Automated classification and characterization of the mitotic spindle following knockdown of a mitosis-related protein.

BMC bioinformatics
BACKGROUND: Cell division (mitosis) results in the equal segregation of chromosomes between two daughter cells. The mitotic spindle plays a pivotal role in chromosome alignment and segregation during metaphase and anaphase. Structural or functional e...

Exposure to Aroclor-1254 impairs spindle assembly during mouse oocyte maturation.

Environmental toxicology
Polychlorinated biphenyls (PCBs), as typical environmental estrogen disruptors, are a structurally-related group of halogenated aromatic hydrocarbons that are composed of 209 isomers and present as a mixture in the environment. PCBs congener with dif...

Deep learning techniques and mathematical modeling allow 3D analysis of mitotic spindle dynamics.

The Journal of cell biology
Time-lapse microscopy movies have transformed the study of subcellular dynamics. However, manual analysis of movies can introduce bias and variability, obscuring important insights. While automation can overcome such limitations, spatial and temporal...