Screening of gastric cancer diagnostic biomarkers in the homologous recombination signaling pathway and assessment of their clinical and radiomic correlations.

Journal: Cancer medicine
PMID:

Abstract

BACKGROUND: Homologous recombination plays a vital role in the occurrence and drug resistance of gastric cancer. This study aimed to screen new gastric cancer diagnostic biomarkers in the homologous recombination pathway and then used radiomic features to construct a prediction model of biomarker expression to guide the selection of chemotherapy regimens.

Authors

  • Ahao Wu
    Department of Digestive Surgery, Digestive Disease Hospital, The First Affiliated Hospital of Nanchang University, Nanchang, 330006, Jiangxi Province, China.
  • Tengcheng Hu
    Department of Digestive Surgery, Digestive Disease Hospital, The First Affiliated Hospital of Nanchang University, Nanchang, 330006, Jiangxi Province, China.
  • Chao Lai
    Department of Digestive Surgery, The First Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, Jiangxi, China.
  • Qingwen Zeng
    Department of Digestive Surgery, Digestive Disease Hospital, The First Affiliated Hospital of Nanchang University, Nanchang, 330006, Jiangxi Province, China.
  • Lianghua Luo
    Department of Digestive Surgery, Digestive Disease Hospital, The First Affiliated Hospital of Nanchang University, Nanchang, 330006, Jiangxi Province, China.
  • Xufeng Shu
    Department of Digestive Surgery, Digestive Disease Hospital, The First Affiliated Hospital of Nanchang University, Nanchang, 330006, Jiangxi Province, China.
  • Pan Huang
    College of Information Science and Engineering, Xinjiang University, Urumqi 830046, China.
  • Zhonghao Wang
    State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangdong Provincial Key Laboratory of Ophthalmology and Vision Science, Guangdong Provincial Clinical Research Center for Ocular Diseases, Guangzhou, China.
  • Zongfeng Feng
    Department of Digestive Surgery, Digestive Disease Hospital, The First Affiliated Hospital of Nanchang University, Nanchang, 330006, Jiangxi Province, China.
  • Yanyan Zhu
    Department of Radiology, The First Affiliated Hospital, Nanchang University, Nanchang, 330006, Jiangxi Province, China.
  • Yi Cao
    Department of Dermatology, First Clinical Medical College of Zhejiang Chinese Medical University, Hangzhou, Zhejiang, China.
  • Zhengrong Li
    Yunnan Diqing Non-ferrous Metals Co., Ltd, Yunnan 674400, China.