Mechanisms of QingRe HuoXue Formula in atherosclerosis Treatment: An integrated approach using Bioinformatics, Machine Learning, and experimental validation.

Journal: International immunopharmacology
PMID:

Abstract

BACKGROUND: Atherosclerosis (AS) is the main cause of coronary heart disease, cerebral infarction, and peripheral vascular disease. QingRe HuoXue Formula (QRHXF), a common prescription of traditional Chinese medicine, has a definite effect on the clinical treatment of AS, but its mechanism remains to be further explored.

Authors

  • Guiting Zhou
    Department of Cardiology, Shunde Hospital of Guangzhou University of Chinese Medicine, Foshan, China; First Clinical Medical College, Guangzhou University of Chinese Medicine, Guangzhou, China.
  • Zhichao Lin
    Department of Instrument Science & Technology, Zhejiang University, Hangzhou, 310027, China.
  • Qing Miao
    School of Mechanical and Electrical Engineering, Wuhan University of Technology, Wuhan, China.
  • Liwen Lin
    First Clinical Medical College, Guangzhou University of Chinese Medicine, Guangzhou, China.
  • Shushu Wang
    First Clinical Medical College, Guangzhou University of Chinese Medicine, Guangzhou, China.
  • Kachun Lu
    First Clinical Medical College, Guangzhou University of Chinese Medicine, Guangzhou, China.
  • Yuling Zhang
    Department of Radiology, Tianjin First Central Hospital, Tianjin, China.
  • Qingmin Chu
    First Clinical Medical College, Guangzhou University of Chinese Medicine, Guangzhou, China; Cardiology Center, The First Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, China; Guangdong Clinical Research Academy of Chinese Medicine, Guangzhou, China.
  • Wanwen Kong
    Department of Cardiology, Shunde Hospital of Guangzhou University of Chinese Medicine, Foshan, China.
  • Kunsheng Wu
    Department of Cardiology, Shunde Hospital of Guangzhou University of Chinese Medicine, Foshan, China.
  • Peijian Liu
    Department of Cardiology, Shunde Hospital of Guangzhou University of Chinese Medicine, Foshan, China.
  • Wei Wu
    Department of Pharmacy, The First Affiliated Hospital, Fujian Medical University, Fuzhou, China.
  • Rui Peng
    Affiliated Nanhua Hospital, University of South China, Hengyang, People's Republic of China.
  • Chuanjin Luo
    First Clinical Medical College, Guangzhou University of Chinese Medicine, Guangzhou, China; Cardiology Center, The First Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, China; Guangdong Clinical Research Academy of Chinese Medicine, Guangzhou, China. Electronic address: gztcm1964@163.com.