AIMC Topic: Collagen Type I, alpha 1 Chain

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Differential gene expression analysis and machine learning identified structural, TFs, cytokine and glycoproteins, including SOX2, TOP2A, SPP1, COL1A1, and TIMP1 as potential drivers of lung cancer.

Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals Feb 10, 2025
BACKGROUND: Lung cancer is a primary global health concern, responsible for a considerable portion of cancer-related fatalities worldwide. Understanding its molecular complexities is crucial for identifying potential targets for treatment. The goal i...
Gene Expression Regulation, Neoplastic Osteopontin Lung Neoplasms SOXB1 Transcription Factors Poly-ADP-Ribose Binding Proteins Tissue Inhibitor of Metalloproteinase-1 Collagen Type I Gene Expression Profiling Gene Regulatory Networks Protein Interaction Maps Machine Learning Biomarkers, Tumor Humans DNA Topoisomerases, Type II Collagen Type I, alpha 1 Chain
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The role of endothelial cell-related gene COL1A1 in prostate cancer diagnosis and immunotherapy: insights from machine learning and single-cell analysis.

Biology direct Jan 8, 2025
BACKGROUND: Endothelial cells are integral components of the tumor microenvironment and play a multifaceted role in tumor immunotherapy. Targeting endothelial cells and related signaling pathways can improve the effectiveness of immunotherapy by norm...
Machine Learning Endothelial Cells Single-Cell Analysis Prostatic Neoplasms Tumor Microenvironment Collagen Type I, alpha 1 Chain Prognosis Humans Collagen Type I Male Immunotherapy
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Identification of novel biomarkers for atherosclerosis using single-cell RNA sequencing and machine learning.

Mammalian genome : official journal of the International Mammalian Genome Society Oct 14, 2024
Atherosclerosis (AS) is a predominant etiological factor in numerous cardiovascular diseases, with its associated complications such as myocardial infarction and stroke serving as major contributors to worldwide mortality rates. Here, we devised depe...
Gene Regulatory Networks Mice Single-Cell Analysis Collagen Type I Collagen Type I, alpha 1 Chain Atherosclerosis Sequence Analysis, RNA Humans Biomarkers Gene Expression Profiling Machine Learning Animals
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Mechanisms of QingRe HuoXue Formula in atherosclerosis Treatment: An integrated approach using Bioinformatics, Machine Learning, and experimental validation.

International immunopharmacology Aug 12, 2024
BACKGROUND: Atherosclerosis (AS) is the main cause of coronary heart disease, cerebral infarction, and peripheral vascular disease. QingRe HuoXue Formula (QRHXF), a common prescription of traditional Chinese medicine, has a definite effect on the cli...
Computational Biology Male Disease Models, Animal Collagen Type I, alpha 1 Chain Machine Learning Gene Expression Profiling Mice Molecular Docking Simulation Collagen Type I Animals Atherosclerosis Humans Drugs, Chinese Herbal Plaque, Atherosclerotic Mice, Inbred C57BL
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