Heat shock protein A12B protects against sepsis-induced impairment in vascular endothelial permeability.

Journal: The Journal of surgical research
Published Date: Dec 30, 2015

Abstract

BACKGROUND: As a common and life-threatening infectious syndrome, sepsis contributes significantly to morbidity and mortality in clinical settings. Vascular endothelial injury and hyperpermeability play an important role in the development of sepsis-induced organ dysfunction. Heat shock protein A12B (HSPA12B) is one of the HSP70 superfamily members and is mainly expressed in vascular endothelial cells. The present study was performed to investigate the role of HSPA12B in endothelial barrier dysfunction during sepsis.

Authors

  • Qiuxiang Kang
    Department of Anesthesiology and Intensive Care Medicine, Changhai Hospital, The Second Military Medical University, Shanghai, China.
  • Yi Chen
    Department of Anesthesiology and Perioperative Medicine, General Hospital of Ningxia Medical University, Yinchuan, China.
  • Xu Zhang
    China CDC Key Laboratory of Environment and Population Health, National Institute of Environmental Health, Chinese Center for Disease Control and Prevention, Beijing 100021, China.
  • Guifang Yu
    Department of Anesthesiology, The Third People's Hospital, Shanghai Jiao Tong University, Shanghai, China.
  • Xiaojian Wan
    Department of Anesthesiology and Intensive Care Medicine, Changhai Hospital, The Second Military Medical University, Shanghai, China.
  • Jiafeng Wang
    Department of Anesthesiology and Intensive Care Medicine, Changhai Hospital, The Second Military Medical University, Shanghai, China.
  • Lulong Bo
    Department of Anesthesiology and Intensive Care Medicine, Changhai Hospital, The Second Military Medical University, Shanghai, China.
  • Keming Zhu
    Department of Anesthesiology and Intensive Care Medicine, Changhai Hospital, The Second Military Medical University, Shanghai, China. Electronic address: kmzhu@aliyun.com.

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