Acute gastrointestinal toxicity and bowel bag dose-volume parameters for preoperative radiation therapy for retroperitoneal sarcoma.

Journal: Practical radiation oncology
Published Date: Dec 19, 2015

Abstract

PURPOSE: Acute gastrointestinal (GI) toxicity has been studied in GI and gynecological (GYN) cancers, with volume receiving 15 Gy (V15) <830 mL, V25 <650 mL, and V45 <195 mL identified as dose constraints for the peritoneal space (bowel bag [BB]). There are no reported constraints derived from retroperitoneal sarcoma (RPS), and prospective trials for RPS have adopted some of the GI and GYN constraints. This study quantified GI toxicity during preoperative radiation therapy (RT) for RPS, assessed toxicity using published constraints, and evaluated predictors for toxicity.

Authors

  • Kimberley S Mak
    Harvard Radiation Oncology Program, Boston, Massachusetts; Department of Radiation Oncology, Boston Medical Center, Boston, Massachusetts.
  • John G Phillips
    Harvard Radiation Oncology Program, Boston, Massachusetts; Department of Radiation Oncology, Dana-Farber Cancer Institute and Brigham and Women's Hospital, Boston, Massachusetts.
  • Constance M Barysauskas
    Department of Biostatistics and Computational Biology, Dana-Farber Cancer Institute, Boston, Massachusetts.
  • Leslie K Lee
    Department of Radiology, Massachusetts General Hospital, Boston, Massachusetts.
  • Edward G Mannarino
    Department of Radiation Oncology, Dana-Farber Cancer Institute and Brigham and Women's Hospital, Boston, Massachusetts.
  • Liam Van Benthuysen
    Department of Radiation Oncology, Massachusetts General Hospital, Boston, Massachusetts.
  • Chandrajit P Raut
    Division of Surgical Oncology, Brigham and Women's Hospital, Boston, Massachusetts; Center for Sarcoma and Bone Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts.
  • John T Mullen
    Department of Surgery, Massachusetts General Hospital, Boston, Massachusetts.
  • Mark Fairweather
    Department of Surgery, Brigham and Women's Hospital, Boston, Massachusetts.
  • Thomas F DeLaney
    Department of Radiation Oncology, Massachusetts General Hospital, Boston, Massachusetts.
  • Elizabeth H Baldini
    Department of Radiation Oncology, Dana-Farber Cancer Institute and Brigham and Women's Hospital, Boston, Massachusetts; Center for Sarcoma and Bone Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts. Electronic address: ebaldini@partners.org.

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