Journal of cancer research and clinical oncology
Jan 8, 2026
PURPOSE: High-dose ifosfamide (HD-IFO) remains an effective regimen for advanced bone and soft tissue sarcomas, but predictors of long-term benefit are poorly defined. This study evaluated clinical outcomes and prognostic factors using machine learni...
The histological FNCLCC grade is the primary prognostic factor in soft-tissue sarcoma (STS) but fails to fully capture high risk patients. This study aimed to develop and validate a deep learning (DL) model to predict metastatic relapse-free survival...
Soft Tissue sarcomas (STS) are a group of heterogeneous and complex diseases where being able to predict the appearance of metastases is key to inform clinical decisions, especially the prescription of adjuvant chemotherapy. We developed SarcNet: a m...
Journal of cancer research and clinical oncology
Sep 10, 2025
PURPOSE: The study aims to compare the treatment recommendations generated by four leading large language models (LLMs) with those from 21 sarcoma centers' multidisciplinary tumor boards (MTBs) of the sarcoma ring trial in managing complex soft tissu...
BACKGROUND: Response to immune checkpoint inhibition (ICI) in sarcomas is overall low and heterogeneous. Understanding determinants of ICI outcomes may improve efficacy and patient selection. Thus, we investigated whether the expression of transposab...
Dermatofibrosarcoma protuberans (DFSP) is a rare, locally aggressive cutaneous sarcoma in which achieving histologically negative margins is paramount to minimizing recurrence. Mohs micrographic surgery (MMS) has transformed margin control in DFSP by...
Oral cancer is a hazardous disease and a major cause of morbidity and mortality worldwide. The purpose of this study was to develop the deep convolutional neural networks (CNN)-based multiclass classification and object detection models for distingui...
PURPOSE: The choice of wound closure modality after limb-sparing extremity soft-tissue sarcoma (eSTS) resection is fraught with uncertainty. Leveraging machine learning and clinicoradiomic data, we developed Sarcoma Reconstruction Nomograms (SARCON),...
This study introduces Raman imaging technique for diagnosing skin cancer in veterinary oncology patients (dogs and cats). Initially, Raman spectral bands (with specificity to certain molecular structures and functional groups) were identified in form...
Critical reviews in oncology/hematology
Mar 24, 2025
The choice of imaging modalities is essential in sarcoma management, as different techniques provide complementary information depending on tumor subtype and anatomical location. This narrative review examines the role of imaging in sarcoma character...
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