A Machine Learning Approach for Predicting Biochemical Outcome After PSMA-PET-Guided Salvage Radiotherapy in Recurrent Prostate Cancer After Radical Prostatectomy: Retrospective Study.

Journal: JMIR cancer
PMID:

Abstract

BACKGROUND: Salvage radiation therapy (sRT) is often the sole curative option in patients with biochemical recurrence after radical prostatectomy. After sRT, we developed and validated a nomogram to predict freedom from biochemical failure.

Authors

  • Ali Janbain
    European Hospital Georges-Pompidou., Clinical research unit, INSERM Clinical Investigation Center., Paris Cité University, Paris, France.
  • Andrea Farolfi
    Division of Nuclear Medicine, IRCCS Azienda Ospedaliero-Universitaria di Bologna, Bologna, Italy.
  • Armelle Guenegou-Arnoux
    European Hospital Georges-Pompidou., Clinical research unit, INSERM Clinical Investigation Center., Paris Cité University, Paris, France.
  • Louis Romengas
    European Hospital Georges-Pompidou., Clinical research unit, INSERM Clinical Investigation Center., Paris Cité University, Paris, France.
  • Sophia Scharl
    Department of Radiation Oncology, University of Ulm, Ulm, Germany.
  • Stefano Fanti
    Medicina Nucleare Metropolitana, Bld 30, AOU Policlinico S. Orsola-Malpighi, Via Massarenti, 9, 40138, Bologna, Italy.
  • Francesca Serani
    Division of Nuclear Medicine, IRCCS Azienda Ospedaliero-Universitaria di Bologna, Bologna, Italy.
  • Jan C Peeken
    Department of Radiation Oncology, Klinikum rechts der Isar, Technical University of Munich (TUM), Ismaninger Straße 22, 81675 Munich, Germany; Deutsches Konsortium für Translationale Krebsforschung (DKTK), Partner Site Munich, Germany.
  • Sandrine Katsahian
    AP-HP, Hôpital Européen Georges Pompidou, Unité de Recherche Clinique, APHP Centre, Paris, France.
  • Iosif Strouthos
    Department of Radiation Oncology, German Oncology Center, University Hospital of the European University, Limassol, Cyprus.
  • Konstantinos Ferentinos
    Department of Radiation Oncology, German Oncology Center, University Hospital of the European University, Limassol, Cyprus.
  • Stefan A Koerber
    Department of Radiation Oncology, Heidelberg University Hospital, Im Neuenheimer Feld 400, 69120, Heidelberg, Germany.
  • Marco E Vogel
    Department of Radiation Oncology, Klinikum rechts der Isar, Technical University of Munich (TUM), Munich, Germany.
  • Stephanie E Combs
    Department of Radiation Oncology, Klinikum rechts der Isar, Technical University of Munich (TUM), Ismaninger Straße 22, 81675 Munich, Germany; Institute of Innovative Radiotherapy (iRT), Department of Radiation Sciences (DRS), Helmholtz Zentrum München, Ingolstaedter Landstrasse 1, 85764 Neuherberg, Germany; Deutsches Konsortium für Translationale Krebsforschung (DKTK), Partner Site Munich, Germany.
  • Alexis Vrachimis
    Department of Nuclear Medicine, German Oncology Center - University Hospital of the European University, Limassol, Cyprus.
  • Alessio Giuseppe Morganti
    Division of Radiation Oncology, IRCCS Azienda Ospedaliero-Universitaria di Bologna, Bologna, Italy.
  • Simon Kb Spohn
    Department of Radiation Oncology, Medical Center-University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany.
  • Anca-Ligia Grosu
    German Cancer Consortium (DKTK), Partner Site Freiburg, Freiburg, Germany.
  • Francesco Ceci
    Department of Oncology and Hemato-Oncology, University of Milan, Milan, Italy.
  • Christoph Henkenberens
    Department of Radiation Oncology, Hannover Medical School, Hannover, Germany.
  • Stephanie Gc Kroeze
    Department of Radiation Oncology, University Hospital Zürich, University of Zurich, Zurich, Switzerland.
  • Matthias Guckenberger
    Department of Radiation Oncology, University Hospital Zurich, Switzerland.
  • Claus Belka
    Department of Radiation Oncology, University Hospital, LMU Munich, Marchioninistr. 15, 81377, Munich, Germany.
  • Peter Bartenstein
    German Cancer Consortium, Heidelberg, Germany.
  • George Hruby
    Department of Radiation Oncology, Northern Sydney Cancer Centre, Royal North Shore Hospital, Reserve Road, St Leonards, NSW, Australia.
  • Louise Emmett
    Garvan Institute of Medical Research and Kinghorn Cancer Centre, Darlinghurst, NSW, Australia.
  • Ali Afshar Omerieh
    Department of Nuclear Medicine, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland.
  • Nina-Sophie Schmidt-Hegemann
    Department of Radiation Oncology KSA-KSB, Cantonal Hospital Aarau, Aarau, Switzerland.
  • Lucas Mose
    Department of Radiation Oncology, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland.
  • Daniel M Aebersold
    Department of Radiation Oncology, Inselspital, Bern University Hospital, and University of Bern, Freiburgstrasse, 3010, Bern, Switzerland.
  • Constantinos Zamboglou
    German Cancer Consortium (DKTK), Partner Site Freiburg, Germany constantinos.zamboglou@uniklinik-freiburg.de.
  • Thomas Wiegel
    Department of Radio Oncology, University Hospital Ulm, Ulm, Germany.
  • Mohamed Shelan
    Department of Radiation Oncology, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland.