Streamlined Intraoperative Brain Tumor Classification and Molecular Subtyping in Stereotactic Biopsies Using Stimulated Raman Histology and Deep Learning.

Journal: Clinical cancer research : an official journal of the American Association for Cancer Research
Published Date: Sep 3, 2024

Abstract

PURPOSE: Recent artificial intelligence algorithms aided intraoperative decision-making via stimulated Raman histology (SRH) during craniotomy. This study assesses deep learning algorithms for rapid intraoperative diagnosis from SRH images in small stereotactic-guided brain biopsies. It defines a minimum tissue sample size threshold to ensure diagnostic accuracy.

Authors

  • David Reinecke
    Department of Stereotactic and Functional Neurosurgery, Center for Neurosurgery, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany.
  • Daniel Rueß
    University of Cologne, Faculty of Medicine and University Hospital Cologne, Department of Stereotactic and Functional Neurosurgery, Cologne, Germany.
  • Anna-Katharina Meissner
    Department of General Neurosurgery, Center for Neurosurgery, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany.
  • Gina Fürtjes
    Department of General Neurosurgery, Center for Neurosurgery, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany.
  • Niklas von Spreckelsen
    Department of General Neurosurgery, Center for Neurosurgery, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany.
  • Adrian Ion-Margineanu
    Invenio Imaging Inc., Santa Clara, California.
  • Florian Khalid
    Invenio Imaging Inc., Santa Clara, California.
  • Tobias Blau
    Institute for Neuropathology, University of Essen, Essen, Germany.
  • Thomas Stehlé
    Department of Renal Physiology, DHU Fire, Bichat Hospital, AP-HP, Paris, France.
  • Abdulkader Al-Shugri
    Institute for Neuropathology, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany.
  • Reinhard Büttner
    Institute of Pathology, University Hospital Cologne, Cologne, Germany.
  • Roland Goldbrunner
    Department of General Neurosurgery, Center for Neurosurgery, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany.
  • Maximilian I Ruge
    Department of Stereotaxy and Functional Neurosurgery, Center for Neurosurgery, Faculty of Medicine and University Hospital Cologne, Kerpener Str. 62, 50937, Cologne, Germany.
  • Volker Neuschmelting
    Department of General Neurosurgery, Center for Neurosurgery, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany.

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