Effect of ethanol extract of nigella sativa L seeds and propofol on BDNF protein level as neuroplasticity and neuroprotection of traumatic brain injury in rats.

Journal: F1000Research
PMID: 39810851

Abstract

BACKGROUND: Traumatic brain injury (TBI) is a change in brain function or evidence of brain pathology caused by external mechanical forces. Brain Derived Neurotrophic Factor (BDNF) is a neurotropin that functions as a neuron protective. Nigella sativa L is reported to have an antioxidant effect, administration of Nigella Sativa L to rats treated with ischemia-reperfusion brain injury. Propofol is an anesthetic agent frequently used intravenously in the management of TBI. The effect of propofol on brain tissue after TBI may be neuroprotective. We aimed to compare the potential of Nigella sativa L and propofol as neuroplasticity and neuroprotection in rats with TBI.

Authors

  • Kulsum Kulsum
    Doctoral Program, Faculty of Medicine, Universitas Syiah Kuala, Banda Aceh, Aceh, 24415, Indonesia.
  • Syahrul Syahrul
    Neurology, Rumah Sakit Umum Daerah Dr Zainoel Abidin, Banda Aceh, Aceh, 24415, Indonesia.
  • Kartini Hasbalah
    Pharmacology, Faculty of Medicine, Universitas Syiah Kuala, Banda Aceh, Aceh, 23111, Indonesia.
  • Ummu Balqis
    Pathology, Faculty of Veterinary, Universitas Syiah Kuala, Banda Aceh, Aceh, 23111, Indonesia.

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