Genetic association of tertiary lymphoid structure-related gene signatures with HCC based on Mendelian randomization and machine learning and construction of prognosis model.

Journal: International immunopharmacology
PMID:

Abstract

BACKGROUND: Tertiary lymphoid structures (TLS) are formed in numerous cancer types. However, their value and significance in hepatocellular carcinoma (HCC) is unclear.

Authors

  • Lei Pu
    The key Laboratory of Adolescent Health Assessment and Exercise Intervention of the Ministry of Education, East China Normal University, Shanghai 200241, PR China. Electronic address: puleiecnu@163.com.
  • Xiaoyan Zhang
    Institute of Information and Navigation, Air Force Engineering University, Xi'an, Shaanxi, China.
  • Cheng Pu
    School of Martial Arts, Shanghai University of Sport, Shanghai 200438, PR China.
  • Jiacheng Zhou
    Department of Interventional Medicine, Liyang Hospital of Chinese Medicine, Jiangsu 213300, PR China.
  • Jianyue Li
    Department of Oncology, Jiangsu Provincial Hospital of Integrated Chinese and Western Medicine, Jiangsu 210046, PR China.
  • Xiaorong Wang
    Ultrasonography Department, First Affiliated Hospital of Xinjiang Medical University, Urumqi, China.
  • Chenpeng Xi
    School of The First Clinical Medical, Shandong University, Shandong 250100, PR China.
  • Chunyuan Zhang