AIMC Topic: Tertiary Lymphoid Structures

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Learnable prototype-guided multiple instance learning for detecting tertiary lymphoid structures in multi-cancer whole-slide pathological images.

Medical image analysis May 23, 2025
Tertiary lymphoid structures (TLS) are ectopic lymphoid aggregates that form under specific pathological conditions, such as chronic inflammation and malignancies. Their presence within the tumor microenvironment (TME) is strongly correlated with pat...
Machine Learning Tumor Microenvironment Humans Multiple-Instance Learning Algorithms Tertiary Lymphoid Structures Neoplasms Image Interpretation, Computer-Assisted
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Automated classification of tertiary lymphoid structures in colorectal cancer using TLS-PAT artificial intelligence tool.

Scientific reports Mar 21, 2025
Colorectal cancer (CRC) ranks as the third most common and second deadliest cancer worldwide. The immune system, particularly tertiary lymphoid structures (TLS), significantly influences CRC progression and prognosis. TLS maturation, especially in th...
Artificial Intelligence Female Humans Tertiary Lymphoid Structures Middle Aged Image Processing, Computer-Assisted Colorectal Neoplasms Aged Adenocarcinoma Male Immunohistochemistry
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Development of a tertiary lymphoid structure-based prognostic model for breast cancer: integrating single-cell sequencing and machine learning to enhance patient outcomes.

Frontiers in immunology Feb 26, 2025
BACKGROUND: Breast cancer, a highly prevalent global cancer, poses significant challenges, especially in advanced stages. Prognostic models are crucial to enhance patient outcomes. Tertiary lymphoid structures (TLS) within the tumor microenvironment ...
Tumor Microenvironment Humans Biomarkers, Tumor Machine Learning Female Prognosis Tertiary Lymphoid Structures Single-Cell Analysis Breast Neoplasms Lymphocytes, Tumor-Infiltrating
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Artificial intelligence-based spatial analysis of tertiary lymphoid structures and clinical significance for endometrial cancer.

Cancer immunology, immunotherapy : CII Feb 1, 2025
With the incorporation of immune checkpoint inhibitors into the treatment of endometrial cancer (EC), a deeper understanding of the tumor immune microenvironment is critical. Tertiary lymphoid structures (TLSs) are considered favorable prognostic fac...
Endometrial Neoplasms Clinical Relevance Middle Aged Lymphocytes, Tumor-Infiltrating Tertiary Lymphoid Structures Prognosis Female Aged Tumor Microenvironment Humans Artificial Intelligence
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Genetic association of tertiary lymphoid structure-related gene signatures with HCC based on Mendelian randomization and machine learning and construction of prognosis model.

International immunopharmacology Nov 19, 2024
BACKGROUND: Tertiary lymphoid structures (TLS) are formed in numerous cancer types. However, their value and significance in hepatocellular carcinoma (HCC) is unclear.
Gene Expression Regulation, Neoplastic Quantitative Trait Loci Female Mendelian Randomization Analysis Tertiary Lymphoid Structures Biomarkers, Tumor Machine Learning Carcinoma, Hepatocellular Humans Male Prognosis Liver Neoplasms
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Cancer-Associated Lymphoid Aggregates in Histology Images: Manual and Deep Learning-Based Quantification Approaches.

Methods in molecular biology (Clifton, N.J.) Jan 1, 2025
Quantification of lymphoid aggregates including tertiary lymphoid structures (TLS) with germinal centers in histology images of cancer is a promising approach for developing prognostic and predictive tissue biomarkers. In this article, we provide rec...
Tertiary Lymphoid Structures Deep Learning Image Processing, Computer-Assisted Algorithms Staining and Labeling Humans Neoplasms Germinal Center
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