Natural Language Processing to Adjudicate Heart Failure Hospitalizations in Global Clinical Trials.

Journal: Circulation. Heart failure
PMID:

Abstract

BACKGROUND: Medical record review by a physician clinical events committee is the gold standard for identifying cardiovascular outcomes in clinical trials, but is labor-intensive and poorly reproducible. Automated outcome adjudication by artificial intelligence (AI) could enable larger and less expensive clinical trials but has not been validated in global studies.

Authors

  • Pablo M Marti-Castellote
    Division of Cardiovascular Medicine, Brigham and Women's Hospital, Boston, MA (P.M.M.-C., B.C., M.P., A.S.D., S.D.S., J.W.C.).
  • Christopher Reeder
    Data Sciences Platform (S.F., C.R., P.D.A., N.D., P.S., G.S., A.A.P., P.B.), Broad Institute of Harvard and the Massachusetts Institute of Technology, Cambridge.
  • Brian Claggett
    Brigham and Women's Hospital, Boston, MA, USA.
  • Pulkit Singh
    Data Sciences Platform (S.F., C.R., P.D.A., N.D., P.S., G.S., A.A.P., P.B.), Broad Institute of Harvard and the Massachusetts Institute of Technology, Cambridge.
  • Emily S Lau
    Cardiovascular Research Center, Department of Medicine (X.W., S.K., L.-C.W., J.P.P., E.S.L., R.V., P.T.E., S.A.L.), Massachusetts General Hospital, Boston.
  • Shaan Khurshid
    Division of Cardiology, Massachusetts General Hospital, Boston, Massachusetts.
  • Puneet Batra
    Data Sciences Platform, Broad Institute of Harvard and the Massachusetts Institute of Technology, Cambridge, Massachusetts.
  • Steven A Lubitz
    Cardiovascular Disease Initiative, Broad Institute of Harvard and the Massachusetts Institute of Technology, Cambridge, Massachusetts.
  • Mahnaz Maddah
    Dana Solutions, Palo Alto, United States.
  • Orly Vardeny
    Center for Care Delivery and Outcomes Research, Minneapolis VA Hospital, University of Minnesota (O.V.).
  • Eldrin F Lewis
    Division of Cardiovascular Medicine, Stanford University School of Medicine, Palo Alto, CA (E.F.L.).
  • Marc Pfeffer
    Division of Cardiovascular Medicine, Brigham and Women's Hospital, Boston, MA (P.M.M.-C., B.C., M.P., A.S.D., S.D.S., J.W.C.).
  • Pardeep Jhund
    British Heart Foundation Cardiovascular Research Centre, University of Glasgow, United Kingdom (P.J., J.J.V.M.).
  • Akshay S Desai
    Division of Cardiovascular Medicine, Brigham and Women's Hospital, Boston, MA (P.M.M.-C., B.C., M.P., A.S.D., S.D.S., J.W.C.).
  • John J V McMurray
    British Heart Foundation Cardiovascular Research Centre, University of Glasgow, United Kingdom (P.J., J.J.V.M.).
  • Patrick T Ellinor
    Cardiovascular Disease Initiative, Broad Institute of Harvard and the Massachusetts Institute of Technology, Cambridge, Massachusetts.
  • Jennifer E Ho
    Division of Cardiology, Massachusetts General Hospital, Boston, Massachusetts.
  • Scott D Solomon
    Brigham and Women's Hospital, Boston, MA, USA.
  • Jonathan W Cunningham
    Cardiovascular Division, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA. Electronic address: jcunningham3@bwh.harvard.edu.