Unraveling pathogenesis and potential biomarkers for autism spectrum disorder associated with HIF1A pathway based on machine learning and experiment validation.

Journal: Neurobiology of disease
PMID: 39657846

Abstract

BACKGROUND: Autism spectrum disorder (ASD) is a neurodevelopmental disorder with a high social burden and limited treatments. Hypoxic condition of the brain is considered an important pathological mechanism of ASD. HIF1A is a key participant in brain hypoxia, but its contribution to the pathophysiological landscape of ASD remains unclear.

Authors

  • Jinru Cui
    Division of Child Healthcare, Department of Pediatrics, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China.
  • Heli Li
    Division of Child Healthcare, Department of Pediatrics, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
  • Cong Hu
    School of Artificial Intelligence and Computer Science, Jiangnan University, Wuxi 214122, China; Jiangsu Provincial Engineering Laboratory of Pattern Recognition and Computational Intelligence, Jiangnan University, Wuxi 214122, China.
  • Feiyan Zhang
    Division of Child Healthcare, Department of Pediatrics, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China.
  • Yunjie Li
    School of Information and Electronics, Beijing Institute of Technology, Beijing 100081, PR China; Department of Civil and Environmental Engineering, University of Washington, Seattle, WA 98195, USA.
  • Ying Weng
    c School of Computer Science , Bangor University , Bangor , UK.
  • Liping Yang
    Department of Emergency, The First People's Hospital of Lianyungang, Lianyungang City, 222002, China.
  • Yingying Li
    Institute of Environment and Health, Jianghan University, Wuhan 430056, China.
  • Minglan Yao
    Department of Pediatrics, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China.
  • Hao Li
    Department of Urology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
  • Xiaoping Luo
    Department of Pediatrics, Tongji Hospital of Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
  • Yan Hao
    Department of Plastic Surgery, Peking Union Medical College Hospital, Beijing, China.

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