AIMC Topic: Microglia
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Integrative transcriptomic analysis reveals oligodendrocyte lineage switching in multiple sclerosis.
Life science alliance
Aug 4, 2025
Multiple sclerosis (MS) is a chronic disease of the central nervous system. The occurrence of MS is a phased process while its cause is still unclear. Here, by combining white matter single-nucleus transcriptomic datasets from MS and control samples,...
Biomarkers and therapeutic strategies targeting microglia in neurodegenerative diseases: current status and future directions.
Molecular neurodegeneration
Jul 10, 2025
Recent advances in our understanding of non-cell-autonomous mechanisms in neurodegenerative diseases (NDDs) have highlighted microglial dysfunction as a core driver of disease progression. Conditions such as Alzheimer's disease (AD), amyotrophic late...
Early transcriptional responses reveal cell type-specific vulnerability and neuroprotective mechanisms in the neonatal ischemic hippocampus.
Acta neuropathologica communications
Jul 5, 2025
Neonatal hypoxic-ischemic (H-I) brain injury, a leading cause of neurodevelopmental disabilities, severely affects the metabolically active and neurogenic hippocampus. To investigate its acute effects and identify drug targets for early therapeutic w...
AI-driven discovery of brain-penetrant Galectin-3 inhibitors for Alzheimer's disease therapy.
Pharmacological research
Jun 19, 2025
Galectin-3 (Gal-3) has emerged as a critical regulator of neuroinflammation and a promising therapeutic target for Alzheimer's disease (AD). Nevertheless, the development of brain-penetrant small-molecule Gal-3 inhibitors poses a significant challeng...
Microglial pruning of glycinergic synapses disinhibits spinal PKCγ interneurons to drive pain hypersensitivity in mice.
Science translational medicine
Jun 18, 2025
Microglial activation is linked to neuroinflammation in neuropathic pain. Recently, microglia-mediated synaptic pruning has received mounting attention. However, the exact role of spinal microglia in modulating neuropathic pain-associated neural circ...
Role of astroglia and microglia in Alzheimer's disease and multiple therapeutic interventions.
Journal of Alzheimer's disease : JAD
Jun 2, 2025
Alzheimer's disease (AD) is characterized by deposition of amyloid-β (Aβ) and neurofibrillary tangles (NFTs) formed by aggregates of hyperphosphorylated tau proteins. It presents a formidable global health challenge, prompting the exploration of inno...
Eyes Are the Windows to the Soul: Reviewing the Possible Use of the Retina to Indicate Traumatic Brain Injury.
International journal of molecular sciences
May 28, 2025
Traumatic brain injury (TBI) induces complex molecular and cellular responses, often leading to vision deterioration and potential mortality. Current objective diagnostic methods are limited, necessitating the development of novel tools to assess dis...
μGlia-Flow, an automatic workflow for microglia segmentation and classification.
Journal of neuroscience methods
Apr 10, 2025
BACKGROUND: Microglia are important immune cells in the central nervous system, playing a key role in various pathological processes. The morphological diversity of microglia is closely linked to the development of brain diseases, yet accurate segmen...
Unveiling CNS cell morphology with deep learning: A gateway to anti-inflammatory compound screening.
PloS one
Mar 21, 2025
Deciphering the complex relationships between cellular morphology and phenotypic manifestations is crucial for understanding cell behavior, particularly in the context of neuropathological states. Despite its importance, the application of advanced i...
S-ketamine exposure in early postnatal period induces social deficit mediated by excessive microglial synaptic pruning.
Molecular psychiatry
Mar 11, 2025
The impact of general anesthetics on neurodevelopment is highly controversial in terms of clinical and preclinical studies. Evidence mounted in recent years indicated development of social cognitions was more susceptible to general anesthesia in earl...
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