AIMC Topic: Hypoxia-Inducible Factor 1, alpha Subunit

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Unraveling pathogenesis and potential biomarkers for autism spectrum disorder associated with HIF1A pathway based on machine learning and experiment validation.

Neurobiology of disease Dec 8, 2024
BACKGROUND: Autism spectrum disorder (ASD) is a neurodevelopmental disorder with a high social burden and limited treatments. Hypoxic condition of the brain is considered an important pathological mechanism of ASD. HIF1A is a key participant in brain...
Humans Machine Learning Biomarkers Autism Spectrum Disorder Female Animals Male Mice Signal Transduction Disease Models, Animal Mice, Inbred C57BL Microglia Hypoxia-Inducible Factor 1, alpha Subunit
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Screening of key biomarkers of tendinopathy based on bioinformatics and machine learning algorithms.

PloS one Oct 29, 2021
Tendinopathy is a complex multifaceted tendinopathy often associated with overuse and with its high prevalence resulting in significant health care costs. At present, the pathogenesis and effective treatment of tendinopathy are still not sufficiently...
Humans Machine Learning Genetic Predisposition to Disease Computational Biology NF-kappa B TOR Serine-Threonine Kinases Vascular Endothelial Growth Factor A Tendinopathy MAP Kinase Signaling System Carboxylic Ester Hydrolases Hypoxia-Inducible Factor 1, alpha Subunit
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[Effect of jianpi-jiedu formula on tumor angiogenesis-relevant genes expression in colorectal cancer].

Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences Dec 28, 2016
To investigate the effect of the jianpi-jiedu formula (JPJD) on the expression of angiogenesis-relevant genes in colon cancer.
 Methods: Crude extract was obtained from JPJD by water extract method. The effect of JPJD crude extract on colon cancer ce...
Humans Colorectal Neoplasms Animals Gene Expression Profiling Cell Line, Tumor Signal Transduction Drugs, Chinese Herbal Blotting, Western TOR Serine-Threonine Kinases STAT3 Transcription Factor Vascular Endothelial Growth Factor A Neovascularization, Pathologic Tumor Suppressor Protein p53 Down-Regulation Up-Regulation Cathepsin B Cathepsins Hypoxia-Inducible Factor 1, alpha Subunit Integrin alpha Chains Receptors, Urokinase Plasminogen Activator Sphingomyelin Phosphodiesterase
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